Duloxetine alleviates oxaliplatin-induced peripheral neuropathy by regulating p53-mediated apoptosis
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DOI: 10.1097/wnr.0000000000001802
Abstract: Oxaliplatin (OXA) is a key platinum-based chemotherapeutic agent for treatment of metastatic colorectal cancer, but the side effects of acute and chronic neuropathies limit its clinical application. Duloxetine has been found to have the potential… read more here.
Keywords: peripheral neuropathy; duloxetine; oxa induced; p53 ... See more keywords
Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway
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DOI: 10.2147/dddt.s224318
Abstract: Purpose Oxaliplatin (OXA)-induced liver injury is one of the main limiting factors affecting the efficacy of OXA-based chemotherapy in patients with colorectal liver metastases. In addition, oxidative stress is an important pathophysiological mechanism of OXA-induced… read more here.
Keywords: liver injury; oxa induced; induced liver; oxidative stress ... See more keywords
Melatonin Mitigates Oxazolone-Induced Colitis in Microbiota-Dependent Manner
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.783806
Abstract: Levels of type 2 cytokines are elevated in the blood and intestinal tissues of ulcerative colitis (UC) patients in the active phase; this phenomenon indicates the participation of type 2 immune response in UC progression.… read more here.
Keywords: oxa induced; colitis microbiota; induced colitis; colitis ... See more keywords
Keratin 17 Promotes T Cell Response in Allergic Contact Dermatitis by Upregulating C–C Motif Chemokine Ligand 20
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.764793
Abstract: Allergic contact dermatitis (ACD) is a delayed-type hypersensitivity response to skin contact allergens in which keratinocytes are critical in the initiation of early responses. Keratin 17 (K17) is a cytoskeletal protein inducible under stressful conditions… read more here.
Keywords: contact; oxa induced; allergic contact; response ... See more keywords
Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.968686
Abstract: Immunogenic cell death (ICD) promotes the immune antitumor response via releasing damage-associated molecular patterns (DAMPs) from dying tumor cells. The induction of autophagy improves the efficacy of multiple immunogenic chemotherapies. Here, we show that piceatannol,… read more here.
Keywords: activation dietary; autophagy activation; oxa induced; dietary piceatannol ... See more keywords
The hepatoprotective role of reduced glutathione and its underlying mechanism in oxaliplatin-induced acute liver injury
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2017.7594
Abstract: Currently, the underlying mechanism of oxaliplatin (OXA) induced live injury is unclear. In addition, there is no standard clinical treatment for OXA-induced acute liver injury (ALI). In this study, we established an animal model of… read more here.
Keywords: induced ali; model; role; injury ... See more keywords