Synthesis of Oxa-spiro-bicyclo[2.1.1]hexane by Au/Sc Relay Catalysis.
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DOI: 10.1021/acs.orglett.5c01542
Abstract: A new Au/Sc relay catalysis approach has been developed for the rapid construction of oxa-spiro-bicyclo[2.1.1]hexanes under mild conditions. This cascade reaction proceeds via a gold-catalyzed cycloisomerization followed by a Sc(OTf)3-catalyzed [3+2] cycloaddition with bicyclo[1.1.0]butanes (BCBs)… read more here.
Keywords: spiro bicyclo; oxa spiro; relay catalysis; bicyclo ... See more keywords