Rhodium-Catalyzed Enantioselective Synthesis of Oxazinones via an Asymmetric Ring Opening-Lactonization Cascade of Oxabicyclic Alkenes.
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DOI: 10.1021/acs.orglett.9b02819
Abstract: The rhodium-catalyzed asymmetric ring opening reaction of oxabicyclic alkenes is shown to be an efficient method for synthesizing chiral heterocycles. We demonstrate that the pairwise combination of chiral catalyst with chiral amino-acid-derived pronucleophiles results in… read more here.
Keywords: ring opening; rhodium catalyzed; asymmetric ring; oxabicyclic alkenes ... See more keywords