Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists.
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DOI: 10.1021/acsmedchemlett.8b00534
Abstract: Recent findings have shown that Farnesoid X Receptor (FXR) antagonists might be useful in the treatment of cholestasis and related metabolic disorders. In this paper, we report the discovery of a new chemotype of FXR… read more here.
Keywords: fxr; fxr antagonists; discovery new; oxadiazole core ... See more keywords