In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions
Sign Up to like & getrecommendations! Published in 2019 at "Xenobiotica"
DOI: 10.1080/00498254.2018.1514545
Abstract: Abstract A 1,2,4-oxadiazole ring-containing compound DS-8500a was developed as a novel G protein-coupled receptor 119 agonist. In vivo metabolic fates of [14C]DS-8500a differently radiolabeled in the benzene ring or benzamide side carbon in rats were… read more here.
Keywords: oxadiazole ring; novel protein; protein coupled; coupled receptor ... See more keywords
New potential biologically active compounds: Synthesis and characterization of urea and thiourea derivatives bearing 1,2,4-oxadiazole ring.
Sign Up to like & getrecommendations! Published in 2020 at "Current organic synthesis"
DOI: 10.2174/1570179417666200417112106
Abstract: BACKGROUND Urea, thiourea, and 1,2,4-oxadiazole compounds are of great interest due to their different activities such as anti-inflammatory, antiviral, analgesic, fungicidal, herbicidal, diuretic, antihelminthic and antitumor along with antimicrobial activities. OBJECTIVE In this work, we… read more here.
Keywords: oxadiazole ring; potential biologically; bearing oxadiazole; urea thiourea ... See more keywords