New indole based hybrid oxadiazole scaffolds with N-substituted acetamides: As potent anti-diabetic agents.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.08.010
Abstract: Current study is based on the sequential conversion of indolyl butanoic acid (1) into ethyl indolyl butanoate (2), indolyl butanohydrazide (3), and 1,3,4-oxadiazole-2-thiol analogs (4) by adopting chemical transformations. In a parallel series of reactions,… read more here.
Keywords: oxadiazole scaffolds; hybrid oxadiazole; scaffolds substituted; based hybrid ... See more keywords
Novel indole based hybrid oxadiazole scaffolds with: N -(substituted-phenyl)butanamides: Synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra04987d
Abstract: In the study presented herein, 4-(1H-indol-3-yl)butanoic acid (1) was sequentially transformed in the first phase into ethyl 4-(1H-indol-3-yl)butanoate (2), 4-(1H-indol-3-yl)butanohydrazide (3) and 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazole-2-thiol (4) as a nucleophile. In the second phase, various electrophiles were synthesized… read more here.
Keywords: oxadiazole scaffolds; novel indole; scaffolds substituted; substituted phenyl ... See more keywords
Groundbreaking Anticancer Activity of Highly Diversified Oxadiazole Scaffolds
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DOI: 10.3390/ijms21228692
Abstract: Nowadays, an increasing number of heterocyclic-based drugs found application in medicinal chemistry and, in particular, as anticancer agents. In this context, oxadiazoles—five-membered aromatic rings—emerged for their interesting biological properties. Modification of oxadiazole scaffolds represents a… read more here.
Keywords: oxadiazole scaffolds; activity highly; anticancer activity; anticancer ... See more keywords
An Understanding of Mechanism-Based Approaches for 1,3,4-Oxadiazole Scaffolds as Cytotoxic Agents and Enzyme Inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020254
Abstract: The world’s health system is plagued by cancer and a worldwide effort is underway to find new drugs to treat cancer. There has been a significant improvement in understanding the pathogenesis of cancer, but it… read more here.
Keywords: mechanism based; oxadiazole scaffolds; approaches oxadiazole; understanding mechanism ... See more keywords