PEGylated PAMAM dendrimers loading oxaliplatin with prolonged release and high payload without burst effect.
Sign Up to like & getrecommendations! Published in 2019 at "Biopolymers"
DOI: 10.1002/bip.23272
Abstract: Oxaliplatin (OXA) was coupled to PEGylated polyamidoamine dendrimers of fourth generation (G4-PEG@OXA) in the comparison to PEGylated ones of odd generation (G3.5-PEG@OXA). Proton nuclear magnetic resonance and Fourier-transform infrared spectroscopy were used to confirm the… read more here.
Keywords: peg oxa; oxa; oxaliplatin; pegylated pamam ... See more keywords
Efficacy and safety of neoadjuvant chemotherapy with oxaliplatin, 5-fluorouracil, and levofolinate for T3 or T4 stage II/III rectal cancer: the FACT trial
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3243-7
Abstract: PurposeA multicenter phase II clinical study was performed in patients with T3 or T4 stage II/III rectal cancer to evaluate the efficacy and safety of neoadjuvant chemotherapy with 5-fluorouracil, levofolinate, and oxaliplatin (mFOLFOX6).MethodsPatients received four… read more here.
Keywords: chemotherapy; rectal cancer; fluorouracil; rate ... See more keywords
EVs delivery of miR-1915-3p improves the chemotherapeutic efficacy of oxaliplatin in colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-021-04348-5
Abstract: Oxaliplatin is a crucial component of the combinatorial chemotherapeutic standard of care for advanced colorectal cancer (CRC). Unfortunately, a serious barrier to effective oxaliplatin treatment is drug resistance due to epithelial-mesenchymal transitioning (EMT). Interestingly, stable… read more here.
Keywords: crc cells; mir 1915; crc; cancer ... See more keywords
Oxaliplatin-induced peripheral neuropathy: clinical features, mechanisms, prevention and treatment
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurology"
DOI: 10.1007/s00415-020-09942-w
Abstract: Oxaliplatin (OXA) is a commonly used platinum-based chemotherapy drug for colorectal cancer. OXA-induced peripheral neurotoxcity (OIPN) is a comprehensive adverse reaction of OXA. OIPN can be divided into acute and chronic types according to clinical… read more here.
Keywords: mechanisms prevention; oxaliplatin; clinical features; induced peripheral ... See more keywords
Behavioral and electromyographic assessment of oxaliplatin-induced motor dysfunctions: Evidence for a therapeutic effect of allopregnanolone
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2016.10.040
Abstract: HighlightsWe validated a rat model of oxaliplatin‐evoked motor neuropathy.Wire suspension and balance beam tests showed motor deficit in OXAL‐treated rats.Motor fiber conductance velocity was reduced in OXAL‐treated rats.OXAL‐treatment increased the compound muscle action potential duration.Allopregnanolone… read more here.
Keywords: oxaliplatin; oxal induced; motor; motor dysfunctions ... See more keywords
A RARE CASE OF OXALIPLATIN-INDUCED PULMONARY FIBROSIS
Sign Up to like & getrecommendations! Published in 2021 at "Chest"
DOI: 10.1016/j.chest.2021.07.717
Abstract: TOPIC: Critical Care TYPE: Medical Student/Resident Case Reports INTRODUCTION: Oxaliplatin is a third generation platinum derivative alkylating agent. The platinum compound binds to the DNA forming crosslink which inhibits DNA replication and transcription, resulting in… read more here.
Keywords: oxaliplatin induced; case; pulmonary fibrosis; oxaliplatin ... See more keywords
Oxaliplatin-induced Immune Thrombocytopenia: A Case Report and Literature Review.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical colorectal cancer"
DOI: 10.1016/j.clcc.2020.07.007
Abstract: Abstract Oxaliplatin-induced immune thrombocytopenia is a rare manifestation of oxaliplatin hypersensitivity, presenting as an acute onset of severe thrombocytopenia after oxaliplatin administration. No standard therapeutic approach outside of permanent discontinuation of oxaliplatin exists. Here, we… read more here.
Keywords: oxaliplatin induced; thrombocytopenia; case; induced immune ... See more keywords
Biodistribution and efficacy of the anticancer drug, oxaliplatin palmitate acetate, in mice.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120740
Abstract: Oxaliplatin palmitate acetate (OPA), a platinum (IV) oxaliplatin derivative, was previously designed with the aim to improve the platinum-based anti-cancer therapy. In this work, we further explore the potential of OPA in extensive in vitro… read more here.
Keywords: palmitate acetate; efficacy; cancer; oxaliplatin ... See more keywords
Oxaliplatin-Induced Peripheral Neuropathy and Identification of Unique Severity Groups in Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pain and symptom management"
DOI: 10.1016/j.jpainsymman.2017.07.033
Abstract: CONTEXT Oxaliplatin-induced peripheral neuropathy (OIPN) is a dose-limiting toxicity of oxaliplatin and affects most colorectal cancer patients. OIPN is commonly evaluated by patient symptom report, using scales to reflect impairment. They do not discriminate between… read more here.
Keywords: oxaliplatin induced; colorectal cancer; severity; identification ... See more keywords
Non cirrhotic portal hypertension secondary to oxaliplatin therapy: Incidence and presentation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hepatology"
DOI: 10.1016/s0168-8278(18)31665-9
Abstract: Background: Recently, several studies have identified a possible relationship between the therapy with oxaliplatin and the development of non-cirrhotic portal hypertension. However, the incidence and the way of presentation of the disease in series of… read more here.
Keywords: therapy; oxaliplatin; hypertension; portal hypertension ... See more keywords
One- and Two-Photon Activated Release of Oxaliplatin from a Pt(IV)-Functionalized Poly(phenylene ethynylene).
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c00859
Abstract: We report a water-soluble poly(phenylene ethynylene) (PPE-Pt(IV)) that is functionalized with oxidized oxaliplatin Pt(IV) units and its use for photoactivated chemotherapy. The photoactivation strategy is based on photoinduced electron transfer from the PPE backbone to… read more here.
Keywords: oxaliplatin; two photon; phenylene ethynylene; release oxaliplatin ... See more keywords