Translation of IDEA trial results into clinical practice: Analysis of the implementation of a new guideline for colon cancer
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DOI: 10.1002/ijc.34149
Abstract: The IDEA trial showed no clinical relevant differences in efficacy between 3 and 6 months of oxaliplatinâbased adjuvant chemotherapy (ACT) in colon cancer (CC), while toxicity was substantially lower in the 3 months regimen. Therefore,… read more here.
Keywords: guideline; act; stage; idea trial ... See more keywords
Phase II study of an oxaliplatin-based regimen for relapsed colon cancer patients treated with oxaliplatin-based adjuvant chemotherapy (INSPIRE study)
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DOI: 10.1007/s00280-021-04232-2
Abstract: The aim of this study was to evaluate the efficacy and safety of first-line chemotherapy with re-introduction of oxaliplatin (OX) more than 6 months after adjuvant chemotherapy including OX. Stage II/III colon cancer patients with… read more here.
Keywords: chemotherapy; adjuvant chemotherapy; study; oxaliplatin based ... See more keywords
Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis
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DOI: 10.1038/s41392-022-00889-0
Abstract: Metabolic enzymes have an indispensable role in metabolic reprogramming, and their aberrant expression or activity has been associated with chemosensitivity. Hence, targeting metabolic enzymes remains an attractive approach for treating tumors. However, the influence and… read more here.
Keywords: panoptosis; oxaliplatin based; chemosensitivity; phosphorylated nfs1 ... See more keywords
Clinicopathological Features and Oncological Outcomes of Early and Late Recurrence in Stage III Colorectal Cancer Patients after Adjuvant Oxaliplatin-Based Therapy
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DOI: 10.1155/2023/2439128
Abstract: Aims An adjuvant oxaliplatin-based regimen is the standard of care for patients with stage III colorectal cancer (CRC). Few reports have compared the clinicopathological features and oncological outcomes of such treatment between patients with early… read more here.
Keywords: based therapy; late recurrence; stage iii; recurrence ... See more keywords
Therapeutic effects of oxaliplatin-based neoadjuvant chemotherapy and chemoradiotherapy in patients with locally advanced rectal cancer: a single-center, retrospective cohort study
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DOI: 10.1186/s12957-018-1403-9
Abstract: BackgroundNeoadjuvant chemoradiotherapy (NACRT) has now become the standard treatment for locally advanced rectal cancer (LARC). NACRT has decreased local relapse (LR) rate in patients with LARC; however, distant relapse has recently attracted much attention. This… read more here.
Keywords: chemotherapy; rectal cancer; year; relapse ... See more keywords
Microsatellite instability and mutations in BRAF and KRAS in small bowel adenocarcinoma.
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DOI: 10.1200/jco.2019.37.15_suppl.e15037
Abstract: e15037 Background: Small-bowel adenocarcinomas (SBAs) are rare cancers with a significantly lower incidence, later stage at diagnosis, and worse overall survival than other intestinal-derived cancers. Activating KRAS and/or BRAF mutations have been identified as predictors… read more here.
Keywords: chemotherapy; small bowel; microsatellite instability; oxaliplatin based ... See more keywords
ASO Author Reflection: Radiomics-Based Prediction for the Responder to First-Line Oxaliplatin-Based Chemotherapy in Patients with Colorectal Liver Metastasis
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DOI: 10.1245/s10434-020-09584-2
Abstract: Curative resection is considered the most definitive strategy for resectable colorectal liver metastases (CRLMs), and such resection is often performed as an initial treatment or after first-line chemotherapy. 1 Oxaliplatin-based regimens are often administered as… read more here.
Keywords: chemotherapy; first line; oxaliplatin based; colorectal liver ... See more keywords
Polymorphisms in DNA repair pathway genes and ABCG2 gene in advanced colorectal cancer: correlation with tumor characteristics and clinical outcome in oxaliplatin-based chemotherapy
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DOI: 10.2147/cmar.s181922
Abstract: Objective Multiple factors are involved in oxaliplatin-resistant process in colorectal cancer (CRC) patients including decreased drug accumulation and enhanced capacity to repair and tolerate DNA damage. In the present study, we aimed to assess the… read more here.
Keywords: based chemotherapy; abcg2 gene; cancer; oxaliplatin based ... See more keywords
Antibiotic Treatment Improves the Efficacy of Oxaliplatin-Based Therapy as First-Line Chemotherapy for Patients with Advanced Gastric Cancer: A Retrospective Study
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DOI: 10.2147/cmar.s353432
Abstract: Purpose One of the first-line treatment for gastric cancer patients is oxaliplatin, and the efficacy of this chemotherapeutic can be attenuated by the microbiome. In this study, we retrospectively evaluated whether treatment with antibiotics improved… read more here.
Keywords: efficacy oxaliplatin; gastric cancer; oxaliplatin based; treatment ... See more keywords
Colorectal Cancer with Peritoneal Metastases: The Impact of the Results of PROPHYLOCHIP, COLOPEC, and PRODIGE 7 Trials on Peritoneal Disease Management
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DOI: 10.3390/cancers15010165
Abstract: Simple Summary Colorectal peritoneal metastases could potentially benefit from locoregional treatments such as cytoreduction combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Three recently published RCTs that have investigated HIPEC in the setting of radical or prophylactic/II^… read more here.
Keywords: prophylochip colopec; peritoneal metastases; based hipec; hipec ... See more keywords
Alterations in IQGAP1 expression and localization in colorectal carcinoma and liver metastases following oxaliplatin-based chemotherapy
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DOI: 10.3892/ol.2017.6525
Abstract: IQGAP1 is a scaffolding protein that serves a key role in cell dynamics by integrating internal and external stimuli to distinct signal outputs. Previous studies have identified several genes that are significantly up- or downregulated… read more here.
Keywords: metastases following; tissue; oxaliplatin based; based chemotherapy ... See more keywords