Rechallenge After Oxaliplatin-Induced Hypersensitivity Reactions.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.7136
Abstract: This cohort study assesses the outcome of oxaliplatin desensitization for patients with gastrointestinal cancers who experienced hypersensitivity reactions after oxaliplatin infusion. read more here.
Keywords: oncology; rechallenge oxaliplatin; oxaliplatin induced; hypersensitivity ... See more keywords
Prognostic value of cutaneous reinnervation with GAP-43 in oxaliplatin-induced neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurology"
DOI: 10.1007/s00415-022-11035-9
Abstract: Oxaliplatin-induced neuropathy (OIN) implies axonal damage of both small and large sensory nerve fibers. We aimed at comparing the neurophysiological changes occurred after treatment and the capability to recovery based on histological marker of re-innervation… read more here.
Keywords: induced neuropathy; oxaliplatin induced; gap; treatment ... See more keywords
A RARE CASE OF OXALIPLATIN-INDUCED PULMONARY FIBROSIS
Sign Up to like & getrecommendations! Published in 2021 at "Chest"
DOI: 10.1016/j.chest.2021.07.717
Abstract: TOPIC: Critical Care TYPE: Medical Student/Resident Case Reports INTRODUCTION: Oxaliplatin is a third generation platinum derivative alkylating agent. The platinum compound binds to the DNA forming crosslink which inhibits DNA replication and transcription, resulting in… read more here.
Keywords: oxaliplatin induced; case; pulmonary fibrosis; oxaliplatin ... See more keywords
Oxaliplatin-induced Immune Thrombocytopenia: A Case Report and Literature Review.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical colorectal cancer"
DOI: 10.1016/j.clcc.2020.07.007
Abstract: Abstract Oxaliplatin-induced immune thrombocytopenia is a rare manifestation of oxaliplatin hypersensitivity, presenting as an acute onset of severe thrombocytopenia after oxaliplatin administration. No standard therapeutic approach outside of permanent discontinuation of oxaliplatin exists. Here, we… read more here.
Keywords: oxaliplatin induced; thrombocytopenia; case; induced immune ... See more keywords
Oxaliplatin-Induced Peripheral Neuropathy and Identification of Unique Severity Groups in Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pain and symptom management"
DOI: 10.1016/j.jpainsymman.2017.07.033
Abstract: CONTEXT Oxaliplatin-induced peripheral neuropathy (OIPN) is a dose-limiting toxicity of oxaliplatin and affects most colorectal cancer patients. OIPN is commonly evaluated by patient symptom report, using scales to reflect impairment. They do not discriminate between… read more here.
Keywords: oxaliplatin induced; colorectal cancer; severity; identification ... See more keywords
First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01911
Abstract: Here, we report for the first time a series of compounds potentially useful for the management of oxaliplatin-induced neuropathy (OINP) able to modulate the human Carbonic Anhydrases (hCAs) as well as the Transient Receptor Potential… read more here.
Keywords: transient receptor; receptor potential; induced neuropathy; oxaliplatin induced ... See more keywords
Oral administration of Cystine and Theanine ameliorates oxaliplatin-induced chronic peripheral neuropathy in rodents
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69674-9
Abstract: Oxaliplatin frequently causes severe peripheral neuropathy as a dose-limiting toxicity. However, this toxicity lacks a strategy for prevention. Cystine/Theanine is a supplement, which includes precursors for the biosynthesis of glutathione. In this study, we investigated… read more here.
Keywords: oxaliplatin induced; theanine; peripheral neuropathy; administration cystine ... See more keywords
Utilizing network pharmacological analysis to investigate the key targets and mechanisms of kaempferol against oxaliplatin-induced neurotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2022.2069531
Abstract: Abstract This study investigated the pharmacological mechanism of kaempferol in the treatment of oxaliplatin-induced neuropathic pain by network pharmacological method and cells experiment. The kaempferol and disease target genes were obtained from several databases, including… read more here.
Keywords: oxaliplatin induced; kaempferol; induced neurotoxicity; network pharmacological ... See more keywords
Chemokine CCL2 and its receptor CCR2 in the dorsal root ganglion contribute to oxaliplatin-induced mechanical hypersensitivity
Sign Up to like & getrecommendations! Published in 2018 at "PAIN"
DOI: 10.1097/j.pain.0000000000001212
Abstract: Abstract Activation of innate immune mechanisms within the dorsal root ganglion and spinal dorsal horn has been shown to play a key role in the development of neuropathic pain including paclitaxel-related chemotherapy-induced peripheral neuropathy (CIPN).… read more here.
Keywords: oxaliplatin induced; induced mechanical; root ganglion; ccl2 ... See more keywords
Oxaliplatin-induced neuropathy occurs via impairment of haemoglobin proton buffering and is reversed by carbonic anhydrase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001722
Abstract: Oxaliplatin is a cornerstone chemotherapeutic used in the treatment of colorectal cancer, the third leading cause of death in Western countries. Most side effects of this platinum-containing drug are adequately managed in the clinic, although… read more here.
Keywords: dorsal root; oxaliplatin induced; carbonic anhydrase; proton ... See more keywords
Sexual dimorphism in the contribution of neuroendocrine stress axes to oxaliplatin-induced painful peripheral neuropathy.
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000002073
Abstract: While clinical studies support the suggestion that stress is a risk factor for painful chemotherapy-induced peripheral neuropathy (CIPN), there is little scientific validation to support this link. Here, we evaluated the impact of stress on… read more here.
Keywords: oxaliplatin induced; stress axes; peripheral neuropathy; stress ... See more keywords