Two Binding Sites of SARS-CoV-2 Macrodomain 3 Probed by Oxaprozin and Meclomen.
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DOI: 10.1021/acs.jmedchem.2c01168
Abstract: Severe acute respiratory syndrome-coronavirus-1/2 (SARS-CoV-1/2) macrodomain 3 (Mac3) is critical for replication and transcription of the viral genome and is therefore a potential therapeutic target. Here, we solved the crystal structure of SARS-CoV-2 Mac3, which… read more here.
Keywords: oxaprozin meclomen; cov mac3; cov macrodomain; binding sites ... See more keywords