Discovery of 3,4-Dihydrobenzo[f][1,4]oxazepin-5(2H)-one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects.
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DOI: 10.1021/acs.jmedchem.1c00672
Abstract: The Traf2- and Nck-interacting protein kinase (TNIK) is a downstream signal protein of the Wnt/β-catenin pathway and has been thought of as a potential target for the treatment of colorectal cancer (CRC) that is often… read more here.
Keywords: dihydrobenzo oxazepin; oxazepin one; tnik inhibitors; colorectal cancer ... See more keywords