Synthesis and Anti-Mycobacterium tuberculosis Activity of Imidazo[2,1-b][1,3]oxazine Derivatives Against Multidrug-Resistant Strains.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300015
Abstract: The emergence of multidrug-resistant strains of M. tuberculosis has raised concerns due to the greater difficulties in patient treatment and higher mortality rates. Herein, we revisited the 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine scaffold and identified potent new carbamate derivatives… read more here.
Keywords: imidazo oxazine; oxazine derivatives; activity; multidrug resistant ... See more keywords
SYNTHESIS OF 1,3-OXAZINE DERIVATIVES BASED ON (–)-ISOPULEGOL USING THE RITTER REACTION AND STUDY OF THEIR ANALGESIC ACTIVITY
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/5739
Abstract: Реакция Риттера между монотерпеноидом (–)-изопулеголом и нитрилами в присутствии концентрированной серной кислоты или трифторметансульфоновой кислоты позволила получить серию хиральных производных 1,3-оксазина. При изучении анальгетической активности синтезированных соединений in vivo обнаружено, что 1,3-оксазин, синтезированный взаимодействием (–)-изопулегола… read more here.
Keywords: synthesis oxazine; isopulegol using; oxazine derivatives; based isopulegol ... See more keywords