Quinolines and Oxazino-quinoline Derivatives as Small Molecule GLI1 Inhibitors Identified by Virtual Screening.
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DOI: 10.1021/acsmedchemlett.2c00249
Abstract: A virtual screening approach based on a five-feature pharmacophoric model for negative modulators of GLI1 was applied to databases of commercially available compounds. The resulting quinoline derivatives showed significant ability to reduce the GLI1 protein… read more here.
Keywords: quinoline derivatives; quinolines oxazino; derivatives small; virtual screening ... See more keywords