Articles with "oxazolo pyridin" as a keyword



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3D‐QSAR and scaffold hopping based designing of benzo[d]ox‐azol‐2(3H)‐one and 2‐oxazolo[4,5‐b]pyridin‐2(3H)‐one derivatives as selective aldehyde dehydrogenase 1A1 inhibitors: Synthesis and biological evaluation

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Published in 2022 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.202200108

Abstract: Aldehyde dehydrogenase 1 (ALDH1A1), an oxidoreductase class of enzymes, is overexpressed in various types of cancer cell lines and is the major cause of resistance to the Food and Drug Administration (FDA)‐approved drug, cyclophosphamide (CP).… read more here.

Keywords: oxazolo pyridin; one oxazolo; qsar; pyridin one ... See more keywords