Abstract 6204: DNA-PK inhibition augment the cancer specific cytotoxicity of mitotic MTH1 inhibitor OXC-101
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DOI: 10.1158/1538-7445.am2023-6204
Abstract: DNA-dependent protein kinase (DNA-PK) plays an important role in the repair of DNA double-strand breaks via the non-homologous end joining (NHEJ) pathway. In addition to its role in the NHEJ pathway, DNA-PK is also known… read more here.
Keywords: inhibition; dna; inhibitor; treatment ... See more keywords
Abstract CT182: OXC-101 shows favorable safety profile in first in human phase 1 trial in patients with advanced solid cancer
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DOI: 10.1158/1538-7445.am2023-ct182
Abstract: Purpose: Many cancers suffer from dysfunctional redox status. MTH1 protects cancer cells from oxidative DNA damage by preventing incorporation of oxidized nucleotides. OXC-101 (Karonudib) is a dual-action mitotic disruptor and MTH1 inhibitor, preventing exit from… read more here.
Keywords: safety; oxc 101; human phase; cancer ... See more keywords