Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20180192
Abstract: Some of the most threatening human diseases are due to a blockage of the mitochondrial electron transport chain (ETC). In a variety of plants, fungi, and prokaryotes, there is a naturally evolved mechanism for such… read more here.
Keywords: alternative oxidase; targeting alternative; oxidase aox; mechanism ... See more keywords
Hypothesized evolutionary consequences of the alternative oxidase (AOX) in animal mitochondria.
Sign Up to like & getrecommendations! Published in 2019 at "Integrative and comparative biology"
DOI: 10.1093/icb/icz015
Abstract: The environment in which eukaryotes first evolved was drastically different from what they experience today, and one of the key limiting factors was the availability of oxygen for mitochondrial respiration. During the transition to a… read more here.
Keywords: basal metazoans; alternative oxidase; oxidase aox; aox ... See more keywords