Design, synthesis and biological evaluation of novel indolinedione–coumarin hybrids as xanthine oxidase inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02589-2
Abstract: A library of indolinedione–coumarin hybrid molecules was rationally designed and synthesized against hyperuricemia. All of the synthesized hybrid molecules were tested to check their inhibitory activity against xanthine oxidase enzyme by using a spectrophotometric assay.… read more here.
Keywords: oxidase enzyme; oxidase; xanthine oxidase; indolinedione coumarin ... See more keywords
Colorimetric Nanobiosensor Design for Determining Oxidase Enzyme Substrates in Food and Biological Samples
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DOI: 10.1021/acsomega.2c06053
Abstract: Biological enzymes have high catalytic activity and unique substrate selectivity; their immobilization may provide cost reduction and reusability. Using magnetic nanoparticles (MNPs) as support materials for enzymes ensures easy separation from reaction media by an… read more here.
Keywords: oxidase enzyme; colorimetric nanobiosensor; determining oxidase; nanobiosensor design ... See more keywords
Inhibitory Effects of Quercetin and Its Human and Microbial Metabolites on Xanthine Oxidase Enzyme
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20112681
Abstract: Quercetin is an abundant flavonoid in nature and is used in several dietary supplements. Although quercetin is extensively metabolized by human enzymes and the colonic microflora, we have only few data regarding the pharmacokinetic interactions… read more here.
Keywords: xanthine oxidase; inhibitory effects; microbial metabolites; enzyme inhibitory ... See more keywords