2‐Benzamido‐4‐methylthiazole‐5‐carboxylic Acid Derivatives as Potential Xanthine Oxidase Inhibitors and Free Radical Scavengers
Sign Up to like & getrecommendations! Published in 2017 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201600313
Abstract: The new chemical entities febuxostat and topiroxostat have been approved by the US Food and Drug Administration, opening new avenues for exploiting different heterocycles other than purines as xanthine oxidase (XO) inhibitors. A different series… read more here.
Keywords: xanthine oxidase; carboxylic acid; benzamido methylthiazole; methylthiazole carboxylic ... See more keywords
Structural exploration of multifunctional monoamine oxidase B inhibitors as potential drug candidates against Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105070
Abstract: AD is one of the most typical neurodegenerative disorders that suffer many seniors worldwide. Recently, MAO inhibitors have received increasing attention not only for their roles involved in monoamine neurotransmitters metabolism and oxidative stress but… read more here.
Keywords: structural exploration; exploration multifunctional; monoamine oxidase; mao inhibitors ... See more keywords
Design, synthesis and biological evaluation of 1-hydroxy-2-phenyl-4-pyridyl-1H-imidazole derivatives as xanthine oxidase inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.060
Abstract: In our previous study, we reported a series of 1-hydroxy-2-phenyl-1H-imidazole-5-carboxylic acid derivatives that presented excellent in vitro xanthine oxidase inhibitory potency. As a continuation study, a series of 1-hydroxy-2-phenyl-1H-imidazole derivatives containing a pyridine moiety (4a-g and… read more here.
Keywords: xanthine oxidase; imidazole derivatives; series; oxidase inhibitors ... See more keywords
EFFECTS OF XANTHINE OXIDASE INHIBITORS ON PROGRESSION OF LEFT ANTERIOR DESCENDING ARTERY ATHEROMA BURDEN
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(18)31782-0
Abstract: Xanthine Oxidoreductase (XOR) has been shown to be involved in the pathogenesis of atherosclerosis via its production of reactive oxygen species. There have been multiple animal studies showing that XOR and reactive oxygen species have… read more here.
Keywords: xanthine oxidase; progression left; left anterior; oxidase inhibitors ... See more keywords
Xanthine oxidase inhibitors are associated with reduced risk of cardiovascular disease
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80835-8
Abstract: As previous studies have reported finding an association between hyperuricemia and the development of cardiovascular and chronic kidney disease, hyperuricemia is thought to be an independent risk factor for hypertension and diabetic mellitus. However, we… read more here.
Keywords: oxidase; xanthine oxidase; risk; oxidase inhibitors ... See more keywords
Shikonin derivatives as potent xanthine oxidase inhibitors: in-vitro study.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2132499
Abstract: Induction of hypersensitivity reactions (may be fatal too) by specific XO inhibitors has led to development of new molecules that are efficacious and have safer ADME profile. Among natural compounds, biologically active Alkannin/Shikonin (A/S) derivatives… read more here.
Keywords: derivatives potent; shikonin derivatives; potent xanthine; shikonin ... See more keywords
P0964EFFECTS OF XANTHINE OXIDASE INHIBITORS AND DAPAGLIFLOZIN ON RENAL GLUCOSE AND URATE TRANSPORTERS IN METABOLIC SYNDROME
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa144.p0964
Abstract: Metabolic syndrome consists of several medical conditions that collectively predict the risk for cardiovascular disease. Hyperglycemia and hyperuricemia are the major disorders of metabolic syndrome. Kidney reabsorbs almost all filtrated glucose by active transport at… read more here.
Keywords: uric acid; xanthine oxidase; high fructose; metabolic syndrome ... See more keywords
Xanthine oxidase inhibitors for prevention of cardiovascular events: a systematic review and meta-analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cardiovascular Disorders"
DOI: 10.1186/s12872-018-0757-9
Abstract: BackgroundXanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties by reducing the production of reactive oxygen species derived from purine metabolism. Oxidative stress is an… read more here.
Keywords: risk; randomized controlled; tce; analysis ... See more keywords
Monoamine oxidase inhibitors (MAOI): pharmacology, metabolism and application in the treatment of depression
Sign Up to like & getrecommendations! Published in 2021 at "Postepy biochemii"
DOI: 10.18388/pb.2021_382
Abstract: The aim of this article is to synthesize informations about monoamine oxidase inhibitors drugs (MAOI) used in the treatment of depression. General informations on monoamine oxidase (MAO) and its kinetic properties are presented. MAO is… read more here.
Keywords: pharmacology; treatment depression; oxidase inhibitors; monoamine oxidase ... See more keywords
The Role of Xanthine Oxidase Inhibitors in Patients with History of Stroke: A Systematic Review.
Sign Up to like & getrecommendations! Published in 2018 at "Current vascular pharmacology"
DOI: 10.2174/1570161115666170919183657
Abstract: BACKGROUND Xanthine oxidase inhibitors are commonly used to lower uric acid levels in patients with gout. Due to their effects on endothelial function, they have also been investigated for possible benefits for patients with cardiovascular… read more here.
Keywords: xanthine oxidase; patients history; oxidase inhibitors; history stroke ... See more keywords
Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.950699
Abstract: Objective: To observe the antioxidative effects of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors (NAY) in vitro and in vivo models of hyperuricemia and explore the mechanism. Methods: A classical experimental method of acute toxicity and a chronic… read more here.
Keywords: ylcarbonyl xanthine; anthraquinone ylcarbonyl; oxidase inhibitors; oxidase ... See more keywords