The Oxidase Reaction of Flavin-Dependent Thymidylate Synthase Reveals the Nature of Inhibitor Binding.
Sign Up to like & getrecommendations! Published in 2025 at "Biochemistry"
DOI: 10.1021/acs.biochem.5c00510
Abstract: Escalating antimicrobial resistance presents an urgent need for novel antibiotics, particularly against Mycobacterium tuberculosis (M. tb), which claims 1.5 million lives annually. A promising avenue for antibiotic development is inhibiting DNA biosynthesis by targeting Thymidylate… read more here.
Keywords: reaction; flavin dependent; oxidase reaction; inhibitor ... See more keywords
Complexity in subnetworks of a peroxidase-oxidase reaction model.
Sign Up to like & getrecommendations! Published in 2022 at "Chaos"
DOI: 10.1063/5.0093169
Abstract: The peroxidase-oxidase (PO) reaction is a paradigmatic (bio)chemical system well suited to study the organization and stability of self-sustained oscillatory phases typically present in nonlinear systems. The PO reaction can be simulated by the state-of-the-art… read more here.
Keywords: oxidase reaction; stability phases; reaction; peroxidase oxidase ... See more keywords
Complex dynamics in an unexplored simple model of the peroxidase-oxidase reaction.
Sign Up to like & getrecommendations! Published in 2023 at "Chaos"
DOI: 10.1063/5.0129095
Abstract: A previously overlooked version of the so-called Olsen model of the peroxidase-oxidase reaction has been studied numerically using 2D isospike stability and maximum Lyapunov exponent diagrams and reveals a rich variety of dynamic behaviors not… read more here.
Keywords: oxidase reaction; peroxidase oxidase; model peroxidase; model ... See more keywords