A Green and Convenient Route for the Regioselective Synthesis of New Substituted 3-Aryl-5H-indeno[1,2-c]pyridazines as Potential Monoamine Oxidase Type A Inhibitors
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DOI: 10.1071/ch16364
Abstract: Several indeno[1,2-c]pyridazines were efficiently synthesised using the one-pot, three-component reaction of substituted indanones, arylglyoxalmonohydrates, and hydrazine in the presence of 1,5-diazabicyclo[4,3,0]non-5-ene (DBN) in water at room temperature. These substituted 3-aryl indeno[1,2-c]pyridazines can be considered as… read more here.
Keywords: potential monoamine; oxidase type; aryl indeno; monoamine oxidase ... See more keywords
Monoamine-Oxidase type B- Inhibitors and Cognitive Functions in Parkinson's Disease: Beyond the Primary Mechanism of Action.
Sign Up to like & getrecommendations! Published in 2022 at "Current neuropharmacology"
DOI: 10.2174/1570159x20666220905102144
Abstract: Symptoms of cognitive impairment are rather common since the early stage of Parkinson's disease (PD), aggravate with disease progression and may lead to dementia in a significant proportion of cases. Worsening of cognitive symptoms in… read more here.
Keywords: parkinson disease; fluctuating patients; mechanism action; type inhibitors ... See more keywords