Modular Oxidation of Cytosine Modifications and Their Application in Direct and Quantitative Sequencing of 5-Hydroxymethylcytosine
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DOI: 10.1021/jacs.3c01663
Abstract: Selective, efficient, and controllable oxidation of cytosine modifications is valuable for epigenetic analyses, yet only limited progress has been made. Here, we present two modular chemical oxidation reactions: conversion of 5-hydroxymethylcytosine (5hmC) into 5-formylcytosine (5fC)… read more here.
Keywords: oxidation; direct quantitative; oxidation cytosine; cytosine modifications ... See more keywords