Assessing the effect of N-oxidation on the mutagenicity of 1-pyrazolines using the Ames assay
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DOI: 10.1093/toxres/tfad036
Abstract: N-Nitrosamines are well known as environmental carcinogens. We have reported that N-nitroso-N-methylbutylamine was oxidized by Fe2+-Cu2+-H2O2 to 5-methyl-5-nitro-1-pyrazoline, a direct-acting N-oxide. 1-Pyrazolines have not been reported to exhibit genotoxicity. In this study, we investigated the… read more here.
Keywords: oxidation mutagenicity; oxidation; effect oxidation; nitro pyrazoline ... See more keywords