Electrochemical-Oxidation-Promoted Direct N-ortho-Selective Difluoromethylation of Heterocyclic N-Oxides.
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DOI: 10.1021/acs.orglett.1c04241
Abstract: An efficient and green electrochemical N-ortho-selective difluoromethylation method of various quinoline and isoquinoline N-oxides has been developed. In this method, sodium difluoromethanesulfinate (HCF2SO2Na) was used as the source of the difluoromethyl moiety, and various N-ortho-selective… read more here.
Keywords: selective difluoromethylation; electrochemical oxidation; oxidation promoted; ortho selective ... See more keywords