Efficient construction of 5H-1,4-benzodiazepine derivatives by a catalyst-free direct aerobic oxidative annulation strategy.
Sign Up to like & getrecommendations! Published in 2021 at "ChemSusChem"
DOI: 10.1002/cssc.202100703
Abstract: A catalyst-free direct aerobic oxidative annulation reaction of 2-aminobenzylic amines and α- hydroxyl ketones can efficiently afford the versatile 5 H -1,4-benzodiazepine derivatives by employing air as the economic and green oxidant under mild conditions.… read more here.
Keywords: direct aerobic; free direct; oxidative annulation; benzodiazepine ... See more keywords
Palladium-Catalyzed Oxidative Annulation of Sulfoximines and Arynes by C-H Functionalization as an Approach to Dibenzothiazines.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02615
Abstract: This work reports a novel and efficient palladium-catalyzed synthesis of tricyclic dibenzothiazines using easily prepared aryl sulfoximines and aryne precursors via C-H functionalization and cyclization. A mechanistic investigation indicated that the C-H bond cleavage at… read more here.
Keywords: oxidative annulation; sulfoximines arynes; annulation sulfoximines; palladium catalyzed ... See more keywords
Palladium-Catalyzed Oxidative Annulation Leading to Substituted Pyrrolo[3,2,1-jk]carbazoles by Sequential C-N and C-C Bond Formation.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00244
Abstract: A novel regioselective annulation of propargylic alcohols with simple carbazoles for the construction of [3,2,1-jk]carbazole scaffolds is described to be the first example of intermolecular synthesis of [3,2,1-jk]carbazoles from simple carbazoles. In situ synthesis of… read more here.
Keywords: catalyzed oxidative; palladium catalyzed; annulation; leading substituted ... See more keywords
A Tandem Oxidative Annulation Strategy for the Synthesis of Tetracyclic 3-Spirooxindole Benzofuranones.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b01374
Abstract: A simple and efficient method was developed for the construction of the medicinally important tetracyclic 3-spirooxindole benzofuranones. In this highly atom- and step-economical one-pot protocol, one quaternary carbon center, two new cycles, and four new… read more here.
Keywords: tandem oxidative; oxidative annulation; spirooxindole benzofuranones; tetracyclic spirooxindole ... See more keywords
Rhodium(III)-Catalyzed Oxidative Annulation of Ketoximes with Sulfonamide: A Direct Approach to Indazoles.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03488
Abstract: A rhodium(III)-catalyzed intermolecular C-H amination of ketoxime and iodobenzene diacetate-enabled N-N bond formation in the synthesis of indazoles has been developed. A variety of functional groups were well tolerated, providing the corresponding products in moderate… read more here.
Keywords: oxidative annulation; ketoximes sulfonamide; iii catalyzed; annulation ketoximes ... See more keywords
Cobalt-Catalyzed Oxidative Annulation of Benzothiophene-[b]-1,1-dioxide through Diastereoselective Double C-H Activation.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03158
Abstract: The use of inexpensive base metal catalysis to perform C-H activation is an active field of research in organic synthesis. Described herein is a sustainable cobalt-catalyzed diastereoselective oxidative annulation/double C-H activation of benzothiophene-[b]-1,1-dioxide with aminoquinolinamides… read more here.
Keywords: oxidative annulation; benzothiophene dioxide; cobalt catalyzed; double activation ... See more keywords
Experimental and Theoretical Studies on Iron-Promoted Oxidative Annulation of Arylglyoxal with Alkyne: Unusual Addition and Migration on the Aryl Ring.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05981
Abstract: An Fe(III)-promoted oxidative annulation reaction was developed for the synthesis of 1,2-naphthoquinones. A variety of substituted arylglyoxals and internal alkynes undergo the transformation in the presence of FeCl3 at room temperature to afford the 1,2-naphthoquinone… read more here.
Keywords: oxidative annulation; addition; arylglyoxal alkyne; promoted oxidative ... See more keywords
Rhodium(iii)-catalyzed regioselective oxidative annulation of anilines and allylbenzenes via C(sp3)-H/C(sp2)-H bond cleavage.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c8cc09099h
Abstract: Described herein is the merging of allylic C(sp3)-H activation and directed C(sp2)-H activation into a single approach for discovering unprecedented chemical transformations. As a proof-of-concept, we disclose for the first time the rhodium-catalyzed regioselective oxidative… read more here.
Keywords: oxidative annulation; rhodium; catalyzed regioselective; anilines allylbenzenes ... See more keywords
Synthesis of 2,4-Diarylquinoline Derivatives via Chloranil-Promoted Oxidative Annulation and One-Pot Reaction
Sign Up to like & getrecommendations! Published in 2020 at "Synthesis"
DOI: 10.1055/s-0039-1691740
Abstract: An oxidative annulation for the synthesis of 2,4-diarylquinolines from o-allylanilines is disclosed that uses recyclable reagent Chloranil as the oxidant. The corresponding products are obtained in moderate to excellent yields. Furthermore, a one-pot access to… read more here.
Keywords: annulation; oxidative annulation; chloranil; one pot ... See more keywords