Gold Catalyzed [3+2] Oxidative Annulation of 1,3‐Enyne with Indole
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202400356
Abstract: An efficient new method has been developed for the synthesis of ketone‐integrated cyclopentene‐fused indoline derivatives with a high regioselectivity through gold‐catalyzed oxidative cyclo‐coupling of 1,3‐enynes with indoles by using 2,6‐dichloropyridine N‐oxide as the terminal oxidant.… read more here.
Keywords: enyne indole; annulation enyne; gold catalyzed; catalyzed oxidative ... See more keywords
Efficient construction of 5H-1,4-benzodiazepine derivatives by a catalyst-free direct aerobic oxidative annulation strategy.
Sign Up to like & getrecommendations! Published in 2021 at "ChemSusChem"
DOI: 10.1002/cssc.202100703
Abstract: A catalyst-free direct aerobic oxidative annulation reaction of 2-aminobenzylic amines and α- hydroxyl ketones can efficiently afford the versatile 5 H -1,4-benzodiazepine derivatives by employing air as the economic and green oxidant under mild conditions.… read more here.
Keywords: direct aerobic; free direct; oxidative annulation; benzodiazepine ... See more keywords
Palladium-Catalyzed Oxidative Annulation of Sulfoximines and Arynes by C-H Functionalization as an Approach to Dibenzothiazines.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02615
Abstract: This work reports a novel and efficient palladium-catalyzed synthesis of tricyclic dibenzothiazines using easily prepared aryl sulfoximines and aryne precursors via C-H functionalization and cyclization. A mechanistic investigation indicated that the C-H bond cleavage at… read more here.
Keywords: oxidative annulation; sulfoximines arynes; annulation sulfoximines; palladium catalyzed ... See more keywords
Palladium-Catalyzed Oxidative Annulation Leading to Substituted Pyrrolo[3,2,1-jk]carbazoles by Sequential C-N and C-C Bond Formation.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00244
Abstract: A novel regioselective annulation of propargylic alcohols with simple carbazoles for the construction of [3,2,1-jk]carbazole scaffolds is described to be the first example of intermolecular synthesis of [3,2,1-jk]carbazoles from simple carbazoles. In situ synthesis of… read more here.
Keywords: catalyzed oxidative; palladium catalyzed; annulation; leading substituted ... See more keywords
A Tandem Oxidative Annulation Strategy for the Synthesis of Tetracyclic 3-Spirooxindole Benzofuranones.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b01374
Abstract: A simple and efficient method was developed for the construction of the medicinally important tetracyclic 3-spirooxindole benzofuranones. In this highly atom- and step-economical one-pot protocol, one quaternary carbon center, two new cycles, and four new… read more here.
Keywords: tandem oxidative; oxidative annulation; spirooxindole benzofuranones; tetracyclic spirooxindole ... See more keywords
Rhodium(III)-Catalyzed Oxidative Annulation of Ketoximes with Sulfonamide: A Direct Approach to Indazoles.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03488
Abstract: A rhodium(III)-catalyzed intermolecular C-H amination of ketoxime and iodobenzene diacetate-enabled N-N bond formation in the synthesis of indazoles has been developed. A variety of functional groups were well tolerated, providing the corresponding products in moderate… read more here.
Keywords: oxidative annulation; ketoximes sulfonamide; iii catalyzed; annulation ketoximes ... See more keywords
Cobalt-Catalyzed Oxidative Annulation of Benzothiophene-[b]-1,1-dioxide through Diastereoselective Double C-H Activation.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03158
Abstract: The use of inexpensive base metal catalysis to perform C-H activation is an active field of research in organic synthesis. Described herein is a sustainable cobalt-catalyzed diastereoselective oxidative annulation/double C-H activation of benzothiophene-[b]-1,1-dioxide with aminoquinolinamides… read more here.
Keywords: oxidative annulation; benzothiophene dioxide; cobalt catalyzed; double activation ... See more keywords
Experimental and Theoretical Studies on Iron-Promoted Oxidative Annulation of Arylglyoxal with Alkyne: Unusual Addition and Migration on the Aryl Ring.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05981
Abstract: An Fe(III)-promoted oxidative annulation reaction was developed for the synthesis of 1,2-naphthoquinones. A variety of substituted arylglyoxals and internal alkynes undergo the transformation in the presence of FeCl3 at room temperature to afford the 1,2-naphthoquinone… read more here.
Keywords: oxidative annulation; addition; arylglyoxal alkyne; promoted oxidative ... See more keywords
Rhodium(iii)-catalyzed regioselective oxidative annulation of anilines and allylbenzenes via C(sp3)-H/C(sp2)-H bond cleavage.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c8cc09099h
Abstract: Described herein is the merging of allylic C(sp3)-H activation and directed C(sp2)-H activation into a single approach for discovering unprecedented chemical transformations. As a proof-of-concept, we disclose for the first time the rhodium-catalyzed regioselective oxidative… read more here.
Keywords: oxidative annulation; rhodium; catalyzed regioselective; anilines allylbenzenes ... See more keywords
I2-Promoted oxidative annulation of three different amines to access diverse biheteroaryls
Sign Up to like & getrecommendations! Published in 2024 at "Organic Chemistry Frontiers"
DOI: 10.1039/d4qo01801j
Abstract: Utilizing tertiary alkylamines as reliable two-carbon building blocks, a concise and efficient route for the regioselective synthesis of biquinolines from 2-methylquinolines and arylamines has been established. This I2-promoted approach enables... read more here.
Keywords: annulation three; amines access; promoted oxidative; three different ... See more keywords
Ru(II)-catalyzed oxidative (4+3) C-H/C-H annulation of 2-aryl-4H-pyrido[1,2-a]pyrimidin-4-ones with allyl alcohol.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d5cc00318k
Abstract: A ruthenium(II)-catalyzed direct oxidative (4+3) C-H/C-H annulation of 2-aryl-4H-pyrido[1,2-a]pyrimidin-4-ones with allyl alcohol has been described. The developed method yielded the corresponding annulated products in moderate to good yields. In addition, based on the control experimental… read more here.
Keywords: annulation; pyrido pyrimidin; pyrimidin ones; aryl pyrido ... See more keywords