P53 knockout mice are protected from cocaine-induced kindling behaviors via inhibiting mitochondrial oxidative burdens, mitochondrial dysfunction, and proapoptotic changes
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DOI: 10.1016/j.neuint.2018.12.017
Abstract: ABSTRACT Previously we demonstrated that p53 mediates dopaminergic neurotoxicity via inducing mitochondrial burdens and proapoptotsis. However, little is known about the role of p53 in the excitotoxicity induced by psychostimulant, such as cocaine. Cocaine‐induced kindling… read more here.
Keywords: depletion p53; cocaine induced; oxidative burdens; cocaine ... See more keywords