Propolis alleviates 4‐aminobiphenyl‐induced oxidative DNA damage by inhibition of CYP2E1 expression in human liver cells
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Toxicology"
DOI: 10.1002/tox.23147
Abstract: 4‐Aminobiphenyl (4‐ABP) may cause DNA damage in human liver cells (HepG2 and L‐02). Propolis exhibits antioxidant properties through reactive oxygen species (ROS) scavenging. We determined the effects of propolis in alleviating 4‐ABP ‐induced DNA damage… read more here.
Keywords: dna damage; cyp2e1 expression; oxidative dna; dna ... See more keywords
Genetic identification and characterization of three genes that prevent accumulation of oxidative DNA damage in Drosophila adult tissues.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.02.013
Abstract: Reactive oxygen species generated in the process of energy production represent a major cause of oxidative DNA damage. Production of the oxidized guanine base, 8-oxo-guanine (8-oxoG), results in mismatched pairing with adenine and subsequently leads… read more here.
Keywords: oxidative dna; dna; drosophila; accumulation ... See more keywords
Understanding the sequence and structural context effects in oxidative DNA damage repair.
Sign Up to like & getrecommendations! Published in 2020 at "DNA repair"
DOI: 10.1016/j.dnarep.2020.102906
Abstract: 8-Oxo-7,8-dihydroguanine (8-oxoG) is the major base damage in the genomic DNA by exposure to reactive oxygen species. Organisms have evolved various DNA repair mechanisms, such as base excision repair (BER) and nucleotide excision repair (NER),… read more here.
Keywords: dna damage; sequence structural; damage repair; oxidative dna ... See more keywords
Insight into an Oxidative DNA-Cleaving DNAzyme: Multiple Cofactors, the Catalytic Core Map and a Highly Efficient Variant
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DOI: 10.1016/j.isci.2020.101555
Abstract: Summary An oxidative DNA-cleaving DNAzyme (PL) employs a double-cofactor model “X/Cu2+” for catalysis. Herein, we verified that reduced nicotinamide adenine dinucleotide (NADH), flavin mononucleotide, cysteine, dithiothreitol, catechol, resorcinol, hydroquinone, phloroglucinol, o-phenylenediamine, 3,3′,5,5'-tetramethylbenzidine, and hydroxylamine acted… read more here.
Keywords: dna cleaving; oxidative dna; cleaving dnazyme; catalytic core ... See more keywords
DNA repair gene OGG1 polymorphism and its relation with oxidative DNA damage in patients with Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134362
Abstract: There is considerable evidence that oxidative DNA damage is increased, DNA repair capacity is decreased in patients with Alzheimer's disease. Base excision repair is the major pathway in removal of oxidative DNA damage. 8-oxo-deoxyguanosine DNA… read more here.
Keywords: dna damage; dna; alzheimer disease; oxidative dna ... See more keywords
Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00038
Abstract: Impaired DNA repair activity has been shown to greatly increase rates of cancer clinically. It has been hypothesized that upregulating repair activity in susceptible individuals may be a useful strategy for inhibiting tumorigenesis. Here, we… read more here.
Keywords: enhancing repair; dna; oxidative dna; dna damage ... See more keywords
Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells
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DOI: 10.1038/s41388-020-1191-x
Abstract: PARP1 and PARP2 play critical roles in regulating DNA repair and PARP inhibitors have been approved for the treatment of BRCA1/2-mutated ovarian and breast cancers. It has long been known that PARP inhibition sensitizes cancer… read more here.
Keywords: dna damage; dna; cancer cells; oxidative dna ... See more keywords
LED-phototherapy does not induce oxidative DNA damage in hyperbilirubinemic Gunn rats
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Research"
DOI: 10.1038/s41390-019-0367-y
Abstract: BackgroundPhototherapy (PT) is the standard treatment of neonatal unconjugated hyperbilirubinemia. Fluorescent tube (FT)-emitted PT light is known to induce oxidative DNA damage in neonates. Nowadays, however, FTs have largely been replaced by light-emitting diodes (LEDs)… read more here.
Keywords: dna damage; induce oxidative; gunn rats; oxidative dna ... See more keywords
Elevated oxidative DNA damage in patients with coronary artery disease and its association with oxidative stress biomarkers
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DOI: 10.1080/00015385.2018.1475093
Abstract: Abstract Objective: The objective of the present study was to evaluate oxidative DNA damage in peripheral blood leukocytes (PBLs) of patients with coronary artery disease (CAD) and to explore the relationship of oxidised purine and… read more here.
Keywords: dna damage; disease; oxidative dna; damage ... See more keywords
Serum cholesterol positively associated with oxidative DNA damage: a propensity score-matched analysis
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DOI: 10.1080/10715762.2019.1595613
Abstract: Abstract Oxidative DNA damage pathogenically links to some major diseases. This study aimed to comprehensively assess the association between serum total cholesterol (TC) and oxidative DNA damage based on propensity score matching (PSM) method. A… read more here.
Keywords: oxidative dna; dna damage; propensity score; serum ... See more keywords
Environmental aircraft noise aggravates oxidative DNA damage, granulocyte oxidative burst and nitrate resistance in Ogg1–/– mice
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DOI: 10.1080/10715762.2020.1754410
Abstract: Abstract Background: Large epidemiological studies point towards a link between the incidence of arterial hypertension, ischaemic heart disease, metabolic disease and exposure to traffic noise, supporting the role of noise exposure as an independent cardiovascular… read more here.
Keywords: dna damage; dna; exposure; oxidative dna ... See more keywords