In vitro Biotransformation of the Nrf2 activator Bardoxolone: Formation of an Epoxide Metabolite that Undergoes Two Novel Glutathione-Mediated Metabolic Pathways; Epoxide Reduction and Oxidative Elimination of Nitrile Moiety.
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DOI: 10.1021/acs.chemrestox.9b00289
Abstract: Metabolism of bardoxolone methyl (BARD-Me), an oleanolic acid derivative, and its epoxide metabolite was studied in different in vitro systems. BARD-Me also undergoes glutathione (GSH)-adduct formation via direct nucleophilic attack at the β-carbon of the… read more here.
Keywords: elimination nitrile; nucleophilic attack; oxidative elimination; epoxide metabolite ... See more keywords