Oxidative N-Heterocyclic Carbene-Catalyzed Intramolecular Friedel-Crafts Alkylation of Indoles for the Synthesis of Spirocyclic Indolenines.
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DOI: 10.1021/acs.orglett.2c01927
Abstract: The stereoselective intramolecular dearomatizing spirocyclization of indoles via oxidative N-heterocyclic carbene (NHC) catalysis to afford indolenines bearing an all-carbon quaternary center at the 3-position is reported. The reaction proceeds via the intramolecular nucleophilic addition of… read more here.
Keywords: catalyzed intramolecular; acyl azolium; carbene catalyzed; oxidative heterocyclic ... See more keywords
Aerobic Oxidative N-Heterocyclic Carbene-Catalyzed Formal [3+3] Cyclization for the Synthesis of Tetrasubstituted Benzene Derivatives
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DOI: 10.1021/acs.orglett.2c03879
Abstract: Herein, we present an accessible aerobic N-heterocyclic carbene (NHC)-catalyzed method that efficiently produces tetrasubstituted benzene rings in a single reaction. The method employs atmospheric oxygen (O2) as the terminal oxidant in a reaction that requires… read more here.
Keywords: aerobic oxidative; carbene catalyzed; heterocyclic carbene; tetrasubstituted benzene ... See more keywords