Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "GeroScience"
DOI: 10.1007/s11357-018-0030-2
Abstract: Inhibition of mTOR signaling using rapamycin has been shown to increase lifespan and healthspan in multiple model organisms; however, the precise mechanisms for the beneficial effects of rapamycin remain uncertain. We have previously reported that… read more here.
Keywords: rapamycin increases; oxidative metabolism; senescence; increases oxidative ... See more keywords
Cerebral Metabolic Changes Related to Oxidative Metabolism in a Model of Bacterial Meningitis Induced by Lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2018 at "Neurocritical Care"
DOI: 10.1007/s12028-018-0509-9
Abstract: BackgroundCerebral mitochondrial dysfunction is prominent in the pathophysiology of severe bacterial meningitis. In the present study, we hypothesize that the metabolic changes seen after intracisternal lipopolysaccharide (LPS) injection in a piglet model of meningitis is… read more here.
Keywords: meningitis; lps injection; metabolic changes; oxidative metabolism ... See more keywords
Metabolic effects of physiological levels of caffeine in myotubes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-017-0601-1
Abstract: Caffeine has been shown to stimulate multiple major regulators of cell energetics including AMP-activated protein kinase (AMPK) and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Additionally, caffeine induces peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and mitochondrial… read more here.
Keywords: physiological levels; metabolism; caffeine; oxidative metabolism ... See more keywords
Sociability trait and regional cerebral oxidative metabolism in rats: Predominantly nonlinear relations
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.08.049
Abstract: HighlightsSocial behaviour of rats, while not independent of the partner, is trait‐like.Mapping oxidative metabolism revealed the brain regions implicated in sociability.The sociability regions are involved in motivation, stress, fear and vigilance.Sociability relates with brain long‐term… read more here.
Keywords: sociability; metabolism; long term; oxidative metabolism ... See more keywords
Bhlhe40 differentially regulates the function and number of peroxisomes and mitochondria in myogenic cells
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2018.10.009
Abstract: PGC-1α is a key regulator of oxidative metabolism facilitating the expression of genes critical for the function and biogenesis of the two key oxidative organelles, mitochondria and peroxisomes, in skeletal muscle (SKM) and other organs.… read more here.
Keywords: oxidative metabolism; number; bhlhe40; expression ... See more keywords
The uremic toxin methylguanidine increases the oxidative metabolism and accelerates the apoptosis of canine neutrophils.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2017.01.006
Abstract: We investigated the hypothesis that the increased concentration of plasma methylguanidine (MG) increases oxidative metabolism and accelerates apoptosis of neutrophils from dogs with chronic kidney disease (CKD). To achieve this, the levels of MG were… read more here.
Keywords: oxidative metabolism; metabolism; metabolism accelerates; increases oxidative ... See more keywords
Unique Oxidative Metabolism of Bufalin Generates Two Reactive Metabolites That Strongly Inactivate Human Cytochrome P450 3A.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01875
Abstract: Identifying the alert groups of mechanism-based inactivators of human cytochrome P450s (hCYPs) is very helpful for early prediction of drug toxicity and for rational drug design to avoid idiosyncratic toxicity. Here, we report that a… read more here.
Keywords: human cytochrome; oxidative metabolism; unique oxidative; bufalin ... See more keywords
Oxidative metabolism of koumine is mainly catalyzed by microsomal CYP3A4/3A5
Sign Up to like & getrecommendations! Published in 2017 at "Xenobiotica"
DOI: 10.1080/00498254.2016.1213925
Abstract: Abstract 1. Gelsemium elegans Benth (Loganiaceae) is a toxic plant that can be used for committing suicide besides alleviating pains. Its anti-inflammatory and analgesic effect mainly come from its active ingredient, namely koumine. Koumine, an indole… read more here.
Keywords: oxidative metabolism; koumine; metabolism koumine; cyp3a4 3a5 ... See more keywords
Recent insights into oxidative metabolism of quercetin: catabolic profiles, degradation pathways, catalyzing metalloenzymes and molecular mechanisms.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2022.2115456
Abstract: Quercetin is the most abundant polyphenolic flavonoid (flavonol subclass) in vegetal foods and medicinal plants. This dietary chemopreventive agent has drawn significant interest for its multiple beneficial health effects ("polypharmacology") largely associated with the well-documented… read more here.
Keywords: oxidative metabolism; recent insights; molecular mechanisms; metabolism quercetin ... See more keywords
Elevated metabolic rate and skeletal muscle oxidative metabolism contribute to the reduced susceptibility of NF‐κB p50 null mice to obesity
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DOI: 10.14814/phy2.13836
Abstract: Mice with a deletion of the p50 subunit of the proinflammatory nuclear factor kappa B pathway (NF‐κB p50) have reduced weight compared to wild‐type control mice. However, the physiological underpinning of this phenotype remains unknown.… read more here.
Keywords: oxidative metabolism; skeletal muscle; p50; mice ... See more keywords
Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201911217
Abstract: Mitochondrial metabolism and the generation of reactive oxygen species (ROS) contribute to the acquisition of DNA mutations and genomic instability in cancer. How genomic instability influences the metabolic capacity of cancer cells is nevertheless poorly… read more here.
Keywords: rely oxidative; parp inhibitors; metabolism; oxidative metabolism ... See more keywords