Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3β Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00520
Abstract: Development of glycogen synthase kinase-3β (GSK-3β) inactivation-centric agents with ploypharmacological profiles is increasingly recognized as a promising therapeutic strategy against the multifactorial etiopathology of Alzheimer's disease (AD). In this respect, a series of disubstituted aminopyrazole… read more here.
Keywords: inflammation; oxidative neurotoxicity; gsk inhibitors; development ... See more keywords
Quercetin Abrogates Oxidative Neurotoxicity Induced by Silver Nanoparticles in Wistar Rats
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12040578
Abstract: This study aimed to investigate the oxidative neurotoxicity induced by silver nanoparticles (AgNPs) and assess the neuroprotective effects of quercetin against this toxicity. Forty adult male rats were divided into four equal groups: control, AgNPs… read more here.
Keywords: oxidative neurotoxicity; induced silver; brain; silver nanoparticles ... See more keywords