Gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13328
Abstract: Although numerous studies have used systemic approaches to identify prognostic predictors in oral squamous cell carcinoma (OSCC), the effectiveness of these approaches has not been assessed clinically. Further, the mechanism underlying malignant behaviors in OSCC… read more here.
Keywords: cell carcinoma; oxidative phosphorylation; squamous cell; gene signature ... See more keywords
Osteoblast‐like MC3T3‐E1 Cells Prefer Glycolysis for ATP Production but Adipocyte‐like 3T3‐L1 Cells Prefer Oxidative Phosphorylation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3390
Abstract: Mesenchymal stromal cells (MSCs) are early progenitors that can differentiate into osteoblasts, chondrocytes, and adipocytes. We hypothesized that osteoblasts and adipocytes utilize distinct bioenergetic pathways during MSC differentiation. To test this hypothesis, we compared the… read more here.
Keywords: atp; mc3t3 cells; cells prefer; osteoblast like ... See more keywords
Mitochondria‐Targeted Antioxidants and Uncouplers of Oxidative Phosphorylation in Treatment of the Systemic Inflammatory Response Syndrome (SIRS)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25626
Abstract: Systemic inflammatory response syndrome (SIRS) development is accompanied by mitochondrial dysfunction and excessive ROS production. Mitochondrial dysfunctions also occur in many SIRS‐related diseases and may be critical for their pathogenesis; therefore, a use of mitochondria‐targeted… read more here.
Keywords: mitochondria targeted; uncouplers oxidative; inflammatory response; systemic inflammatory ... See more keywords
Astrocytic Changes in Mitochondrial Oxidative Phosphorylation Protein Levels in Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2021 at "Movement Disorders"
DOI: 10.1002/mds.28849
Abstract: Mitochondrial dysfunction within neurons, particularly those of the substantia nigra, has been well characterized in Parkinson's disease and is considered to be related to the pathogenesis of this disorder. Dysfunction within this important organelle has… read more here.
Keywords: oxidative phosphorylation; astrocytic changes; mitochondrial oxidative; disease ... See more keywords
QcrB in Mycobacterium tuberculosis: The new drug target of antitubercular agents
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal Research Reviews"
DOI: 10.1002/med.21779
Abstract: Drug‐resistance in mycobacterial infections is a major global health problem that leads to high mortality and socioeconomic pressure in developing countries around the world. From finding new targets to discovering novel chemical scaffolds, there is… read more here.
Keywords: target; qcrb mycobacterium; drug; tuberculosis ... See more keywords
Mesenchymal stem cells from preterm to term newborns undergo a significant switch from anaerobic glycolysis to the oxidative phosphorylation
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2665-z
Abstract: We evaluated the energy metabolism of human mesenchymal stem cells (MSC) isolated from umbilical cord (UC) of preterm ( read more here.
Keywords: term; anaerobic glycolysis; stem cells; oxidative phosphorylation ... See more keywords
Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "GeroScience"
DOI: 10.1007/s11357-018-0030-2
Abstract: Inhibition of mTOR signaling using rapamycin has been shown to increase lifespan and healthspan in multiple model organisms; however, the precise mechanisms for the beneficial effects of rapamycin remain uncertain. We have previously reported that… read more here.
Keywords: rapamycin increases; oxidative metabolism; senescence; increases oxidative ... See more keywords
Uncovering proteomics changes of Penicillium expansum spores in response to decanal treatment by iTRAQ
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Plant Pathology"
DOI: 10.1007/s42161-020-00486-6
Abstract: Exogenous decanal can significantly inhibit the germination and development of postharvest pathogen Penicillium expansum in vitro. Through an iTRAQ-based analysis, a global view of proteomic alteration of P. expansum spores under decanal treatment was acquired.… read more here.
Keywords: expansum spores; penicillium expansum; decanal treatment; itraq ... See more keywords
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.022
Abstract: Understanding metabolic pathways that regulate Th17 development is important to broaden therapeutic options for Th17-mediated autoimmunity. Here, we report a pivotal role of mitochondrial oxidative phosphorylation (OXPHOS) for lineage specification toward pathogenic Th17 differentiation. Th17… read more here.
Keywords: fate decision; mitochondrial oxidative; th17; oxidative phosphorylation ... See more keywords
Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.08.012
Abstract: Enhanced glucose uptake and a switch to glycolysis are key traits of M1 macrophages, whereas enhanced fatty acid oxidation and oxidative phosphorylation are the main metabolic characteristics of M2 macrophages. Recent studies challenge this traditional… read more here.
Keywords: oxidative phosphorylation; differentiation; macrophage differentiation; glycolytic stimulation ... See more keywords
Impairment of mitochondrial oxidative phosphorylation in skin fibroblasts of SALS and FALS patients is rescued by in vitro treatment with ROS scavengers
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2021.113620
Abstract: Amyotrophic lateral sclerosis (ALS) is a devastating, rapidly progressive, neurodegenerative disorder affecting upper and lower motor neurons. Approximately 10% of patients suffer from familial ALS (FALS) with mutations in different ubiquitously expressed genes including SOD1,… read more here.
Keywords: impairment mitochondrial; sals fals; mitochondrial oxidative; oxidative phosphorylation ... See more keywords