Synthesis of 3,3-Dialkylated Oxindoles by Oxidative Radical 1,2-Alkylarylation of α,β-Unsaturated Amides
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DOI: 10.1055/s-0036-1588754
Abstract: 3,3-Dialkylated oxindoles (1,3-dihydro-2 H -indol-2-ones), particularly those containing C3 quaternary stereogenic centers, occupy an important place in organic synthesis and drug discovery. The radical 1,2-alkylarylation of activated olefins with alkyl radicals has emerged as the… read more here.
Keywords: radical alkylarylation; unsaturated amides; dialkylated oxindoles; synthesis ... See more keywords