Inhibition of glycolysis disrupts cellular antioxidant defense and sensitizes HepG2 cells to doxorubicin treatment
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DOI: 10.1002/2211-5463.12628
Abstract: Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy… read more here.
Keywords: inhibition glycolysis; glycolysis; hepg2 cells; antioxidant defense ... See more keywords
Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1
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DOI: 10.1002/2211-5463.12634
Abstract: Oxidative stress and abnormal osteocyte apoptosis are often related to dysregulation of bone turnover and chronic bone loss, and so fruit and vegetables with high antioxidant potential may play an important role in the prevention… read more here.
Keywords: blueberry juice; bone; oxidative stress;
XBP1 inhibits mesangial cell apoptosis in response to oxidative stress via the PTEN/AKT pathway in diabetic nephropathy
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DOI: 10.1002/2211-5463.12655
Abstract: Diabetic nephropathy (DN) is a complication of diabetes mellitus (DM) that frequently results in renal disease, and is characterized by a variety of symptoms, including albuminuria. It has been shown that apoptosis of glomerular mesangial… read more here.
Keywords: pten akt; apoptosis; oxidative stress; cell apoptosis ... See more keywords
Analogs of imine resveratrol alleviate oxidative stress‐induced neurotoxicity in PC12 cells via activation of Nrf2
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DOI: 10.1002/2211-5463.13209
Abstract: Oxidative stress is closely associated with neurodegenerative, cardiovascular and metabolic diseases. Resveratrol and related compounds have shown great potential as antioxidants via either direct scavenging of abundant reactive oxygen species (ROS) or activation of the… read more here.
Keywords: resveratrol; pc12 cells; imine resveratrol; activation ... See more keywords
Obesity‐induced oxidative stress and mitochondrial dysfunction negatively affect sperm quality
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DOI: 10.1002/2211-5463.13589
Abstract: Obesity is a systemic metabolic disease that can induce male infertility or subfertility through oxidative stress. The aim of this study was to determine how obesity impairs sperm mitochondrial structural integrity and function, and reduces… read more here.
Keywords: obesity; sperm quality; stress; oxidative stress ... See more keywords
Oxidative stress in the tumor microenvironment in gastric cancer and its potential role in immunotherapy.
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DOI: 10.1002/2211-5463.13630
Abstract: Gastric cancer (GC) is the fourth leading cause of cancer-related death and the fifth most common malignant tumor globally. However, the clinical efficacy of conventional therapies is limited. Currently, immunotherapy is considered an effective therapeutic… read more here.
Keywords: oxidative stress; cancer; tumor microenvironment; gastric cancer ... See more keywords
Ultrasound Detection of Regional Oxidative Stress in Deep Tissues Using Novel Enzyme Loaded Nanoparticles
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DOI: 10.1002/adhm.201601163
Abstract: Oxidative stress is a powerful tool that is critical to immune mediated responses in healthy individuals, yet additionally plays a crucial role in development of cancer, inflammatory pathologies, and tissue ischemia. Despite this, there remain… read more here.
Keywords: deep tissues; stress; stress deep; enzyme loaded ... See more keywords
Effective Sonosensitizer Delivery by Redox Sensitive Nanoparticles for Prostate Cancer Sonodynamic Therapy via Amplifying Oxidative Stress and Peroxidation
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DOI: 10.1002/adhm.202201472
Abstract: Sonodynamic therapy (SDT), a novel noninvasive therapeutic modality, provides many noteworthy benefits by generating reactive oxygen species (ROS). However, water‐insoluble sonosensitizer delivery strategies have continuously underperformed because of unavoidable toxicity and a short circulation time.… read more here.
Keywords: stress; prostate cancer; sonosensitizer; oxidative stress ... See more keywords
Surfactant Semiconductors as Trojan Horses in Cell‐Membranes for On‐Demand and Spatial Regulation of Oxidative Stress
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DOI: 10.1002/adhm.202202290
Abstract: Oxidative stress is a cause for numerous diseases and aging processes. Thus, researchers are keen to tune the level of intracellular stress and to learn from that. An unusual approach is presented here. The methodology… read more here.
Keywords: stress; trojan horses; surfactant semiconductors; semiconductors trojan ... See more keywords
Oxidative Stress Amplifiers as Immunogenic Cell Death Nanoinducers Disrupting Mitochondrial Redox Homeostasis for Cancer Immunotherapy
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DOI: 10.1002/adhm.202202710
Abstract: Reactive oxygen species (ROS)‐induced oxidative stress in the endoplasmic reticulum (ER) is generally believed to be an important prerequisite for immunogenic cell death (ICD) which can trigger antitumor immune responses for cancer immunotherapy. However, thus… read more here.
Keywords: cell; stress; oxidative stress; cancer ... See more keywords
Glutamine‐Based Metabolism Normalization and Oxidative Stress Alleviation by Self‐Assembled Bilirubin/V9302 Nanoparticles for Psoriasis Treatment
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DOI: 10.1002/adhm.202203397
Abstract: Psoriasis is an immune‐mediated chronic inflammatory skin disorder characterized by epidermal hyperplasia and infiltration of inflammatory cells. Even though the pathogenesis remains unclear, T helper 17 (Th17) cells‐mediated inflammation and keratinocyte‐involved proliferation are considered to… read more here.
Keywords: metabolism; oxidative stress; self; psoriasis ... See more keywords