Multicomponent Oxidative Trifluoromethylation of Alkynes with Photoredox Catalysis: Synthesis of α-Trifluoromethyl Ketones.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00410
Abstract: The direct oxidative addition of CF3 and H2O to alkynes was achieved with photoredox catalysis to obtain α-trifluoromethyl ketones via rapid enol-keto tautomerization. The reaction exhibits high functional group tolerance and regioselectivity. Heterocycles of various… read more here.
Keywords: trifluoromethyl ketones; multicomponent oxidative; trifluoromethylation alkynes; oxidative trifluoromethylation ... See more keywords
Copper-catalyzed remote C(sp3)–H azidation and oxidative trifluoromethylation of benzohydrazides
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08741-w
Abstract: The Hofmann-Löffler-Freytag (HLF) reaction is a prototypical example of radical-based remote functionalization of unactivated C(sp3)–H bond. While 1,5-hydrogen atom transfer (1,5-HAT) of the amidyl radical is thermodynamically favorable and is well-established, the method for the… read more here.
Keywords: trifluoromethylation; remote sp3; azidation oxidative; oxidative trifluoromethylation ... See more keywords
Metal-free oxidative trifluoromethylation of indoles with CF3SO2Na on the C2 position
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra07785e
Abstract: An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CF3SO2Na under metal-free conditions is described, which selectively introduces trifluoromethyl to indoles on the C2 position. read more here.
Keywords: free oxidative; position; indoles cf3so2na; metal free ... See more keywords