Pyridine-N-Oxide Alkaloids from Allium stipitatum and Their Synthetic Disulfide Analogs as Potential Drug Candidates against Mycobacterium tuberculosis: A Molecular Docking, QSBAR, and ADMET Prediction Approach
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/6261528
Abstract: In this study, we consider pyridine-N-oxide alkaloids from Allium stipitatum and their synthetic disulfide analogs (PDAs) as candidates for next-generational antimycobacterial agents, in light of growing resistance to existing conventional therapies. In silico studies involving… read more here.
Keywords: tuberculosis; oxide alkaloids; pyridine oxide; allium stipitatum ... See more keywords
New N-oxide alkaloids from the stems of Sinomenium acutum.
Sign Up to like & getrecommendations! Published in 2022 at "Fitoterapia"
DOI: 10.2139/ssrn.4281979
Abstract: Six new alkaloids (1-6) and six known alkaloids (7-12) were obtained from the stems of Sinomenium acutum. Among them, compounds 1-3 and 6 were four N-oxide alkaloids. The structures and absolute configurations of these new… read more here.
Keywords: alkaloids stems; stems sinomenium; oxide alkaloids; new oxide ... See more keywords