Nitric oxide metabolites: associations with cardiovascular biomarkers and clinical parameters in patients with HFpEF
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14116
Abstract: Heart failure with preserved ejection fraction (HFpEF) is one of the most rapidly growing cardiovascular health burden worldwide, but there is still a lack of understanding about the HFpEF pathophysiology. The nitric oxide (NO) signalling… read more here.
Keywords: associations cardiovascular; metabolites associations; oxide metabolites; nitric oxide ... See more keywords
The Effect of Retroconversion Metabolism of N-oxide Metabolites by Intestinal Microflora on Piperaquine Elimination in Mice, as well as in Humans Predicted Using a PBPK Model.
Sign Up to like & getrecommendations! Published in 2023 at "Current drug metabolism"
DOI: 10.2174/1389200224666230320112429
Abstract: BACKGROUND Piperaquine (PQ) and its pharmacologically active metabolite PQ N-oxide (PM1) can be metabolically interconverted via hepatic cytochrome P450 and FMO enzymes. OBJECTIVES The reductive metabolism of PM1 and its further N-oxidation metabolite (PM2) by… read more here.
Keywords: metabolism; oxide metabolites; reduction metabolism; elimination ... See more keywords