Iridium-Catalyzed Highly Enantioselective Transfer Hydrogenation of Aryl N-Heteroaryl Ketones with N-Oxide as a Removable ortho-Substituent.
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DOI: 10.1021/acs.orglett.7b03878
Abstract: A highly enantioselective transfer hydrogenation of non-ortho-substituted aryl N-heteroaryl ketones, using readily available chiral diamine-derived iridium complex (S,S)-1f as a catalyst and sodium formate as a hydrogen source in a mixture of H2O/i-PrOH (v/v =… read more here.
Keywords: heteroaryl ketones; transfer hydrogenation; enantioselective transfer; oxide removable ... See more keywords