The oxidized‐LDL/LOX‐1 axis in tumor endothelial cells enhances metastasis by recruiting neutrophils and cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34134
Abstract: Epidemiological relationships between cancer and cardiovascular diseases have been reported, but a molecular basis remains unclear. Some proteoglycans that strongly bind low‐density‐lipoprotein (LDL) are abundant both in atherosclerotic regions and in high metastatic‐tumor tissue. LDL… read more here.
Keywords: lox; metastasis; oxidized ldl; tumor ... See more keywords
Elaborate evaluation of serum and tissue oxidized LDL level with darapladib therapy: A feasible diagnostic marker for early atherogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Asian pacific Journal of Tropical Biomedicine"
DOI: 10.1016/j.apjtb.2016.11.014
Abstract: Objective To compare oxidized low density lipoprotein (oxLDL) levels in serum and vascular wall of Sprague-Dawley rats, identify their patterns in 8 weeks and 16 weeks of dyslipidemia induced by high fat diet, compare foam… read more here.
Keywords: oxidized ldl; tissue oxidized; ldl level; serum tissue ... See more keywords
Oxidized LDL triggers changes in oxidative stress and inflammatory biomarkers in human macrophages
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2017.11.017
Abstract: Oxidized low-density lipoprotein (oxLDL) is a well-recognized proatherogenic particle that functions in atherosclerosis. In this study, we established conditions to generate human oxLDL, characterized according to the grade of lipid and protein oxidation, particle size… read more here.
Keywords: oxidized ldl; isop; ldl triggers; thp macrophages ... See more keywords
Novel and traditional lipid profiles in Metabolic Syndrome reveal a high atherogenicity
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48120-5
Abstract: Low-density-lipoprotein cholesterol (LDL-c) guides lipid-lowering therapy, although other lipid parameters could better reflect cardiovascular disease (CVD) risk. Discordance between these parameters and LDL-c has not been evaluated in metabolic syndrome (MetS) patients. We characterized a… read more here.
Keywords: target; oxidized ldl; metabolic syndrome; non hdl ... See more keywords
Role of Lectin-like Oxidized LDL Receptor-1 and Syncytiotrophoblast Extracellular Vesicles in the Vascular Reactivity of Mouse Uterine Arteries During Pregnancy
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63205-2
Abstract: Vascular complications in pregnancy (e.g. preeclampsia) are a major source of maternal and foetal morbidity and mortality, and may be due to excessive release of placental syncytiotrophoblast-derived extracellular vesicles (STBEVs) into the maternal circulation. Increased… read more here.
Keywords: extracellular vesicles; like oxidized; oxidized ldl; receptor ... See more keywords
Oxidized LDL receptors: a recent update.
Sign Up to like & getrecommendations! Published in 2023 at "Current opinion in lipidology"
DOI: 10.1097/mol.0000000000000884
Abstract: PURPOSE OF REVIEW LDL in its oxidized form, or 'oxLDL', is now generally acknowledged to be highly proatherogenic and to play a significant role in atherosclerotic plaque formation. Therefore, there has been increasing interest in… read more here.
Keywords: receptors recent; development; ldl receptors; oxidized ldl ... See more keywords
Highly oxidized low‐density lipoprotein mediates activation of monocytes but does not confer interleukin‐1β secretion nor interleukin‐15 transpresentation function
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1111/imm.13142
Abstract: Oxidized low‐density lipoprotein (LDL) contributes to cardiovascular disease in part by mediating activation and maturation of monocytes and macrophages. Furthermore, co‐localization studies using histochemical approaches have implicated a potential role for oxidized LDL as a… read more here.
Keywords: oxidized ldl; secretion; transpresentation; highly oxidized ... See more keywords
Circulating oxidized LDL, increased in patients with acute myocardial infarction, is accompanied by heavily modified HDL[S]
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Lipid Research"
DOI: 10.1194/jlr.ra119000312
Abstract: Oxidized LDL (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was fractionated on an anion-exchange column, in… read more here.
Keywords: oxidized ldl; patients acute; ldl; ldl fraction ... See more keywords
A study on serum homocysteine and oxidized LDL as markers of cardiovascular risk in patients with overt hypothyroidism
Sign Up to like & getrecommendations! Published in 2022 at "Hormone Molecular Biology and Clinical Investigation"
DOI: 10.1515/hmbci-2021-0029
Abstract: Abstract Objectives Hypothyroidism is the most common endocrine disorder worldwide. Hypothyroisim increases cardiovascular risk, thus the study focuses on the assessment of cardiovascular risk factors such as serum Homocysteine, serum Oxidized LDL and Lipid profile… read more here.
Keywords: risk; cardiovascular risk; serum homocysteine; oxidized ldl ... See more keywords
Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2021 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202114365
Abstract: Arrhythmogenic cardiomyopathy (ACM) is hallmarked by ventricular fibro‐adipogenic alterations, contributing to cardiac dysfunctions and arrhythmias. Although genetically determined (e.g., PKP2 mutations), ACM phenotypes are highly variable. More data on phenotype modulators, clinical prognosticators, and etiological… read more here.
Keywords: oxidized ldl; dependent pathway; pathway new; ldl dependent ... See more keywords
Oxidized-LDL is a useful marker for predicting the very early coronary artery disease and cardiovascular outcomes.
Sign Up to like & getrecommendations! Published in 2018 at "Personalized medicine"
DOI: 10.2217/pme-2018-0046
Abstract: AIM The link of oxidized-low-density lipoprotein (ox-LDL) with premature coronary artery disease (CAD) has previously been less examined. Materials & methods: A total of 1217 patients with angiography-proven CAD were consecutively enrolled and divided into very-early CAD (VECAD),… read more here.
Keywords: ldl useful; oxidized ldl; coronary artery; artery disease ... See more keywords