The proofreading activity of Pfprex from Plasmodium falciparum can prevent mutagenesis of the apicoplast genome by oxidized nucleotides
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-67853-2
Abstract: The DNA polymerase module of the Pfprex enzyme (PfpPol) is responsible for duplication of the genome of the apicoplast organelle in the malaria parasite. We show that PfpPol can misincorporate oxidized nucleotides such as 8oxodGTP… read more here.
Keywords: apicoplast genome; proofreading activity; prevent mutagenesis; oxidized nucleotides ... See more keywords
Rice Nudix Hydrolase OsNUDX2 Sanitizes Oxidized Nucleotides
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DOI: 10.3390/antiox11091805
Abstract: Nudix hydrolase (NUDX) hydrolyzes 8-oxo-(d)GTP to reduce the levels of oxidized nucleotides in the cells. 8-oxo-(d)GTP produced by reactive oxygen species (ROS) is incorporated into DNA/RNA and mispaired with adenine, causing replicational and transcriptional errors.… read more here.
Keywords: osnudx2 gene; oxidized nucleotides; oxo dgtp; osnudx2 ... See more keywords