Oxidized phospholipids in Doxorubicin-induced cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.01.032
Abstract: Doxorubicin (Dox), a widely used chemotherapy drug, can also cause cardiotoxic effects leading to heart failure. The excessive oxidative stress caused by Dox results in the modification of a variety of cellular molecules, including phospholipids.… read more here.
Keywords: oxidized phospholipids; doxorubicin induced; induced cardiotoxicity; phospholipids doxorubicin ... See more keywords
Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation
Sign Up to like & getrecommendations! Published in 2019 at "Nature immunology"
DOI: 10.1038/s41590-019-0539-2
Abstract: Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory gene expression to changes in macrophage metabolism, both of which influence subsequent inflammatory activities. Similar to their microbial counterparts, several self-encoded damage-associated molecular patterns (DAMPs)… read more here.
Keywords: oxidized phospholipids; hyperinflammation; phospholipids reprogram; metabolism ... See more keywords
Low Concentrations of Oxidized Phospholipids Increase Stress Tolerance of Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11091741
Abstract: Oxidized phospholipids (OxPLs) are generated by enzymatic or autooxidation of esterified polyunsaturated fatty acids (PUFAs) residues. OxPLs are present in circulation and atherosclerotic plaques where they are thought to induce predominantly proinflammatory and toxic changes… read more here.
Keywords: lyso pls; endothelial cells; oxpls lyso; low concentrations ... See more keywords