Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation
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DOI: 10.1038/s41467-019-09288-6
Abstract: Isomerases perform biotransformations without cofactors but often cause an undesirable mixture of substrate and product due to unfavorable thermodynamic equilibria. We demonstrate the feasibility of using an engineered yeast strain harboring oxidoreductase reactions to overcome… read more here.
Keywords: oxidoreductive reactions; equilibrium; biotransformation; isomerization reaction ... See more keywords