A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue
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DOI: 10.1038/s41557-018-0082-z
Abstract: Creating designer enzymes with the ability to catalyse abiological transformations is a formidable challenge. Efforts toward this goal typically consider only canonical amino acids in the initial design process. However, incorporating unnatural amino acids that… read more here.
Keywords: designer; hydrazone oxime; oxime formation; designer enzymes ... See more keywords
Oxime formation coordination-directed detection of genome-wide thymine oxides with nanogram-scale sample input
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DOI: 10.1039/d2sc03013f
Abstract: Natural chemical modifications of nucleic acids play a vital role in life processes. Compared to other epigenetic modifications, there are multiple ways to quantify the methylated derivatives of cytosine. However, simple and convenient methods for… read more here.
Keywords: sample input; oxime formation; thymine oxides; formation coordination ... See more keywords