Articles with "oxindole" as a keyword



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Asymmetric [3+2] cycloaddition of 3-amino oxindole-based azomethine ylides with α,β-ynones: a straightforward approach to spirooxindoles incorporating 2,5-dihydropyrroles and pyrroles.

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Published in 2017 at "Chemical communications"

DOI: 10.1039/c7cc01653k

Abstract: An organocatalytic asymmetric [3+2] cycloaddition of 3-amino oxindole-based azomethine ylides and α,β-ynones has been developed. This reaction afforded spiro[dihydropyrrole-2,3'-oxindole] products in high chemical yields with excellent stereoselectivities (up to 99% yields, >20 : 1 dr and >99%… read more here.

Keywords: based azomethine; oxindole based; amino oxindole; cycloaddition amino ... See more keywords

Regio- and stereoselective synthesis of spiropyrrolidine-oxindole and bis-spiropyrrolizidine-oxindole grafted macrocycles through [3 + 2] cycloaddition of azomethine ylides

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Published in 2020 at "RSC Advances"

DOI: 10.1039/c9ra10463a

Abstract: A convenient and efficient method for the regioselective macrocyclization of triazole bridged spiropyrrolidine-oxindole, and bis-spiropyrrolizidine-oxindole derivatives was accomplished through intra and self-intermolecular [3 + 2] cycloaddition of azomethine ylides. The chalcone isatin precursors 9a–i required… read more here.

Keywords: oxindole; spiropyrrolidine oxindole; spiropyrrolizidine oxindole; cycloaddition azomethine ... See more keywords