MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?☆
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2016.11.002
Abstract: &NA; 8‐Oxo‐7,8‐dihydroguanine (GO) can originate as 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine 5′‐triphosphate (8‐oxo‐dGTP), an oxidized form of dGTP in the nucleotide pool, or by direct oxidation of guanine base in DNA. Accumulation of GO in cellular genomes can result… read more here.
Keywords: accumulation; oxo dgtp; mth1; nucleotide pool ... See more keywords
Visualizing the three-metal-ion-dependent cleavage of a mutagenic nucleotide
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207180119
Abstract: The accurate replication, transcription, and maintenance of genetic material requires housekeeping enzymes that prevent the spontaneous mutagenesis of DNA by catalyzing the removal of oxidized deoxynucleoside triphosphates (dNTPs). These include the Nudix hydrolase superfamily member… read more here.
Keywords: metal ion; visualizing three; mth1; oxo dgtp ... See more keywords
Rice Nudix Hydrolase OsNUDX2 Sanitizes Oxidized Nucleotides
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11091805
Abstract: Nudix hydrolase (NUDX) hydrolyzes 8-oxo-(d)GTP to reduce the levels of oxidized nucleotides in the cells. 8-oxo-(d)GTP produced by reactive oxygen species (ROS) is incorporated into DNA/RNA and mispaired with adenine, causing replicational and transcriptional errors.… read more here.
Keywords: osnudx2 gene; oxidized nucleotides; oxo dgtp; osnudx2 ... See more keywords