Ultrasensitive and Single-Base Resolution Quantification of 8-Oxo-7,8-dihydroguanine in DNA by Extension and Ligation-Based qPCR.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01679
Abstract: Oxidative DNA damage is tightly linked to the development of multiple age-related diseases. The prominent oxidation product is 8-oxo-7,8-dihydroguanine (OG), which has been proved to be an important epigenetic-like biomarker. Quantification of the locus-specific OG… read more here.
Keywords: base resolution; quantification; dna; oxo dihydroguanine ... See more keywords
8-Oxo-7,8-dihydroguanine in the Context of a Gene Promoter G-Quadruplex Is an On–Off Switch for Transcription
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DOI: 10.1021/acschembio.7b00636
Abstract: Interplay between DNA repair of the oxidatively modified base 8-oxo-7,8-dihydroguanine (OG) and transcriptional activation has been documented in mammalian genes. Previously, we synthesized OG into the VEGF potential G-quadruplex sequence (PQS) in the coding strand… read more here.
Keywords: transcription; oxo dihydroguanine; strand; base ... See more keywords
Chemical labeling achieves 8-oxo-7,8-dihydroguanine mapping in the microRNA transcriptome.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06273a
Abstract: A labeling chemistry-based methodology, APSC-8-oxoGua-seq, is developed to sequence 8-oxoGua in the microRNA transcriptome. N-(3-Azidopropyl)-spermine-5-carboxamide (APSC) is designed for the selective labeling of 8-oxoGua, where its azide facilitates the conjugation of a cleavable linker via… read more here.
Keywords: oxo dihydroguanine; microrna transcriptome; chemical labeling; achieves oxo ... See more keywords
Increased production of 8-oxo-7,8-dihydroguanine in human urine, a novel biomarker of osteoporosis
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2022.2106224
Abstract: Abstract Osteoporosis is a worldwide disease that seriously affects the quality of life and survival rate of the elderly. The detection of bone biomarkers will provide supplementary information on bone mineral density, contributing to the… read more here.
Keywords: oxo; oxo dihydro; oxo dihydroguanine; oxogsn ... See more keywords