4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL.
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DOI: 10.1021/acsmedchemlett.4c00384
Abstract: Rhomboid proteases play a variety of physiological roles, but rhomboid protease inhibitors have been mostly developed for the E. coli model rhomboid GlpG. In this work, we screened different electrophilic scaffolds against the human mitochondrial… read more here.
Keywords: oxo lactams; parl; covalent inhibitors; inhibitors mitochondrial ... See more keywords