Synthesis of a Fluorinated Derivative of Sigma-1 Receptor Modulator E1R: 2-[5-oxo-3-phenyl-2-(trifluoromethyl)pyrrolidin-1-yl]Acetamide
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-020-02814-1
Abstract: The ozonation of N-Boc-protected 3-methylidene-4-phenyl-5-(trifluoromethyl)pyrrolidin-2-one resulted in its transformation into 3-hydroxy-4-phenyl-5-(trifluoromethyl)-3-pyrrolin-2-one. Catalytic hydrogenation of its O-Boc-protected derivative introduced a way to reduce the double bond in combination with elimination of the hydroxy group leading to… read more here.
Keywords: phenyl trifluoromethyl; trifluoromethyl pyrrolidin; phenyl; synthesis fluorinated ... See more keywords
Effect of annealing and UV irradiation on structural and optical properties of 6-(3,4 Dimethoxyphenyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro1Hpyrazolo[4,3-b]-5-carbonitrile thin films
Sign Up to like & getrecommendations! Published in 2017 at "Optical Materials"
DOI: 10.1016/j.optmat.2017.04.065
Abstract: Abstract 6-(3,4 Dimethoxyphenyl)-1-methyl-3-oxo-2-phenyl-2,3 dihydro1Hpyrazolo[4,3-b]-5-carbonitrile, DMOPC, is a newly synthesized organic compound. DMOPC showed polycrystalline structure and crystallizes in monoclinic crystal system. The deposited thin films showed nanocrystals embedded in amorphous medium. The optical constants of… read more here.
Keywords: thin films; phenyl dihydro1hpyrazolo; dimethoxyphenyl methyl; methyl oxo ... See more keywords
Reduction of chromano-piperidine-fused isoxazolidines: Tandem intramolecular rearrangements leading to 2-(methylamino)-4-oxo-N-phenyl-N-propyl-4H-chromene-3-carboxamide
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DOI: 10.1016/j.tetlet.2017.05.032
Abstract: Reductive ring opening of isoxazolidine moiety of chromano–piperidine-fused isoxazolidines (3a–c) with HCOONH4 and 10% Pd/C in a mixture of solvents (THF/MeOH) at ambient temperature, affords novel 2-(methylamino)-4-oxo-N-phenyl-N-propyl-4H-chromene-3-carboxamide (4), which is apparently derived from reductive NO… read more here.
Keywords: methylamino oxo; oxo phenyl; chromano piperidine; piperidine fused ... See more keywords
The formation of cage phosphoranes and their rearrangements in the reactions of substituted 2-(3-oxo-3-phenyl)ethoxybenzo[d]-1,3,2-dioxaphospholes with perfluorodiacetyl.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc02941j
Abstract: The Kukhtin-Ramirez reaction of 2-(3-oxo-3-phenyl)ethoxy-benzo[d]-1,3,2-dioxaphospholes with perfluorodiacetyl was monitored by NMR methods. To our surprise the initial stage involved a kinetically controlled [4+4]-cycloaddition with the formation of a cage phosphorane containing a 2',5',8',9'-tetraoxa-2λ5-phosphaspiro[benzo[d][1,3,2]dioxaphosphole-2,1'-bicyclo[4.2.1]nonan]-3'-ene (compound 5)… read more here.
Keywords: dioxaphospholes perfluorodiacetyl; compound; formation cage; oxo phenyl ... See more keywords
Crystal structures and Hirshfeld surface analyses of 2-amino-4-(4-bromophenyl)-6-oxo-1-phenyl-1,4,5,6-tetrahydropyridine-3-carbonitrile hemihydrate and 1,6-diamino-2-oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile
Sign Up to like & getrecommendations! Published in 2022 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989022007356
Abstract: In 2-amino-4-(4-bromophenyl)-6-oxo-1-phenyl-1,4,5,6-tetrahydropyridine-3-carbonitrile hemihydrate, pairs of molecules of are joined by pairs of N—H⋯N hydrogen bonds, producing a dimer with an (12) ring pattern. Further N—H⋯Br and O—H⋯O hydrogen bonds, as well as C—Br⋯π interactions, link… read more here.
Keywords: amino bromophenyl; tetrahydropyridine carbonitrile; phenyl tetrahydropyridine; bromophenyl oxo ... See more keywords
Products of complexation in the Cu(CH3CОО)2–2-(7-bromo-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl)acetohydrazide–salicylaldehyde–isopropanol system
Sign Up to like & getrecommendations! Published in 2017 at "Russian Journal of Inorganic Chemistry"
DOI: 10.1134/s0036023617020139
Abstract: Copper(II) complexes isolated from the Cu(CH3COO)2–2-(7-bromo-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl)acetohydrazide (Hydr)–salicylaldehyde (HSal)–isopropanol system [Cu2(HydrSal)2(μ-CH3COO)] (I), [Cu(HydrSal)2] (II) (HydrSal (hydrazone)is the condensation product of hydrazide and salicylaldehide) are synthesized and investigated. The complexes are characterized by elemental analysis, electrical conductivity… read more here.
Keywords: benzodiazepin acetohydrazide; phenyl benzodiazepin; bromo oxo; isopropanol system ... See more keywords