Enantioselective benzylation of methyl 4-oxo-3-piperidinecarboxylate with cinchona alkaloids phase-transfer catalysts
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DOI: 10.1080/00397911.2018.1496259
Abstract: Abstract The asymmetric benzylation of methyl 4-oxo-3-piperidinecarboxylate has been investigated, and methyl (R)-1,3-dibenzyl-4-oxopiperidine-3-carboxylate (3c) was obtained by using a phase-transfer catalyst O-allyl-N-9-anthracenemethyl-cindexnine bromide (1k). This synthetic method has the advantages of cheap materials, mild reaction… read more here.
Keywords: methyl oxo; phase transfer; benzylation methyl; oxo piperidinecarboxylate ... See more keywords