Biosynthesis of Vitroprocines by α-Oxoamine Synthase and Oxidoreductase Identified from Vibrio sp. QWI-06.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01178
Abstract: A specific α-oxoamine synthase (VsAOS-2) and an oxidoreductase (VsOR) identified from marine Vibrio sp. QWI-06 were involved in the decarboxylative condensation of l-tyrosine to lauroyl-CoA following the reduction of the ketone group to form vitroprocine-type… read more here.
Keywords: oxidoreductase; oxoamine synthase; biosynthesis vitroprocines; vitroprocines oxoamine ... See more keywords
Understanding and Circumventing the Requirement for Native Thioester Substrates for α-Oxoamine Synthase Reactions.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00365
Abstract: Many enzyme classes require thioester electrophiles such as acyl-carrier proteins and acyl-coenzyme A substrates. For in vitro applications, these substrates can render these chemical transformations impractical. To address this challenge, we have investigated the mechanism… read more here.
Keywords: oxoamine synthase; understanding circumventing; native thioester; circumventing requirement ... See more keywords