Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors.
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DOI: 10.1016/j.bioorg.2017.04.006
Abstract: Lysine specific demethylase 1 (LSD1) is a flavin-dependent amine oxidase that selectively removes one or two methyl groups from H3 at Lys4 and is recognized as a promising therapeutic target for cancer and other diseases.… read more here.
Keywords: design synthesis; oxoamino benzenesulfonamides; reversible lsd1; lsd1 inhibitors ... See more keywords